Skeletal Muscle Adaptation in Response to Supervised Exercise Training for Intermittent Claudication

Beckitt TA, Day J, Morgan M, et al (Bristol Royal Infirmary, UK) Eur J Vasc Endovasc Surg 44:313-317, 2012^§

Abstract

Objectives

There is evidence that the improvement following supervised exercise for claudication results from skeletal muscle adaptation. The myosin heavy chain (MHC) determines muscle fibre type and therefore efficiency. Immunohistochemical analysis has failed to take account of hybrid MHC expression within myofibres. This study sought evidence of differential MHC protein expression following supervised exercise for claudication.

Design

38 claudicants were recruited. Subjects undertook a three-month supervised exercise programme. Controls were patients awaiting angioplasty for claudication.

Materials and Methods

Subjects underwent paired gastrocnemius biopsy. Relative expression of MHC proteins was determined by SDS-PAGE electrophoresis. Non-parametric data is presented as median with the inter-quartile range and parametric as the mean ± standard deviation.

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