Multidetector CT imaging with cardiac gating is ideally used to assess pericardial anatomy and cardiac function with adequate temporal and high spatial resolution. However, nongated multidetector CT is usually adequate for diagnosis of pericardial disease.

Electrocardiogram-gated MRI studies with morphologic and functional sequences allow a complete evaluation of the pericardium with high soft-tissue contrast and spatial resolution. Images of the entire heart can be acquired with a few breath-holds or during free-breathing. New techniques with a phased-arrayed coil can image the heart with a high temporal resolution.

Turbo spin-echo (SE) T1-weighted images are usually acquired at least in the axial and coronal planes for morphologic assessment of the pericardium. SE or inversion
recovery gradient echo (GRE) images after administration of gadolinium chelates may be used to detect enhancement caused by inflammatory processes of the pericardium. Cine MR images using GRE or steady-state free precession sequences are acquired to evaluate ventricular function, ventricular sliding motion over the pericardium, and diastolic ventricular septal motion.

The pericardium is a compliant sac that envelops the heart and the origin of the great vessels. It is attached to the sternum anteriorly and to the diaphragm inferiorly. The left atrium is only partially covered by the pericardium. Parietal pericardium consists of fibrous tissue with an inner layer of mesothelial cells that reflect in the regions of pericardial attachment and cover the surface of the heart, forming the visceral pericardium (6). On MRI and CT studies, the normal pericardium is usually less than 2 mm thick (Figs. 12.1 and 12.2). A thickness greater than 4 mm is considered abnormal (7,8). CT can overestimate pericardial thickness in the presence of isodense effusion (2). Visualization of the pericardium on both CT and MRI is possible because of its position between two fat planes (epicardial and pericardial). Although the pericardium is visible over the right cardiac chambers in most studies, it may not be visible over the lateral and posterior walls of the left ventricle (7).

The pericardial cavity normally contains up to 50 mL of serous fluid that distributes diffusely around the heart surface and inside the pericardial recesses (6). The complex configuration of the pericardial cavity can be understood as two connected complex spaces surrounding the heart and great vessels (9). The first region surrounds the proximal two-thirds of the ascending aorta and pulmonary artery out to its bifurcation, and is known as transverse sinus (Fig. 12.3) (9,10). The second region surrounds the attachment of the inferior vena cava, superior vena cava, and pulmonary veins, delineating a cul-de-sac behind the left atrium called oblique sinus (Fig. 12.4). The pericardial cavity has several recesses that can be recognized on CT and MR images: These are the superior and inferior aortic recesses, left and right pulmonic recesses, posterior pericardial recess, left
and right pulmonary vein recesses, and postcaval recess (Fig. 12.5) (9,11,12).

Knowledge of the cross-sectional anatomy of the pericardial recesses is essential for its differentiation from lymph nodes or abnormalities of adjacent mediastinal structures (13,14,15 and 16). In the setting of malignancy, a misinterpretation of a normal recess as lymphadenopathy could lead to inappropriate staging of tumors (17). Occasionally, one of the recesses can be much more prominent than the others, increasing the chances of misinterpretation (Fig. 12.6).

Normal pericardial fluid resides in the recesses of normal individuals. Fluid is invariably observed in one or more recesses on CT and MRI in the absence of a pericardial effusion. One or more recesses may be particularly prominent in some normal subjects.

The pericardium is composed of fibrous tissue and appears dark on T1- and T2-weighted SE images (Fig. 12.2). In the area of the right ventricle, it is located between the prominent bright pericardial and epicardial fat, which provides a natural high level of contrast, so that the sensitivity for the visualization of the pericardium in this region is 100% (7). In regions adjacent to the lung, the natural contrast is lower, so that the sensitivity for visualization in the area of the lateral wall of the left ventricle is lower. The thickness of the pericardium on MR images ranges from 1 to 3 mm. Anatomic studies have shown the thickness of the pericardium to be in the range of 0.4 to 1 mm. The overestimation on MRI has been presumed to result from motion-induced signal loss of the normal pericardial fluid, which cannot be readily distinguished from the pericardium itself. Pericardial thickness depends also on the anatomic level and increases toward the diaphragm. This effect results from the ligamentous insertion of the pericardium into the diaphragm and from its tangential direction to the imaging plane in axial images. Consequently, the measurement of pericardial thickness is most reliable at the midventricular level.

The pericardial space normally contains 10 to 50 mL of fluid. In most normal subjects, pericardial fluid can be identified in the pericardial recesses on CT and MRI. The numerous etiologies of pericardial effusion are listed in Table 12.1. For many pericardial effusions, the etiology is never established. The effusion is recognized as an incidental finding on echocardiography, CT, or MRI. The procedure of choice for evaluation of the presence and size of pericardial effusion is transthoracic echocardiography. Collections of fluid within the pericardial cavity can represent transudate or exudates. The latter include serous, fibrinous, purulent, and hemorrhagic or (rarely) chylous pericardial effusion (18).

Simple pericardial effusion (transudate) has a density close to water on CT (– 20 to 20 Hounsfield units) (Fig. 12.7).
The typical appearance on MRI is low signal intensity on T1-weighted SE and high signal intensity on T2-weighted SE, cine GRE, and steady-state free precession sequences (Fig. 12.8) (4,19,20).

Differentiation of transudate from exudates is usually not possible based on imaging appearance alone. However, increased fluid density and heterogeneity on CT suggest exudates. On MRI, intermediate signal on T1-weighted spin-echo images suggests exudates (Fig. 12.9) (4).

The appearance of pericardial hematoma depends on the age of the pericardial blood. Acute hemopericardium has a high density on CT (greater than 40 to 50 Hounsfield units), whereas subacute hematomas present with a heterogeneous density (Fig. 12.10). MRI of acute pericardial hematoma shows a high signal intensity on SE T1-weighted sequences and a low signal intensity on cine GRE images (21,22). Subacute and chronic hematomas are usually heterogeneous with both high and low signal intensity regions on T1-weighted images (Fig. 12.11) (23,24). Distinguishing features of pericardial hematoma compared to nonhemorrhagic effusion are summarized in Table 12.2.

Chylous effusion is extremely rare. It has been described as a low-density pericardial collection on CT.

Small amounts of pericardial fluid can be misinterpreted on CT imaging because of similar appearance to pericardial thickening (2,4). Cine MRI (steady-state free precession sequences) can distinguish between the high intensity of a small simple effusion and the adjacent low signal of normal parietal pericardium. However, small volume of fluid and pericardium may be indistinguishable on spin-echo MRI and thereby simulate pericardial thickening. Pericardial effusion shows no increase in signal on T1-weighted images after administration of gadolinium chelate. This feature aids in distinguishing between pericardial fluid and pericardial or myocardial tumor on T1-weighted SE images. CT and MRI are very sensitive for the detection of generalized or loculated pericardial effusions. CT and MRI can detect pericardial fluid volume as small as 30 mL (4

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