Background
Delivering energy at sub-ablative temperatures appears to produce contraction of the mitral valve annulus (MA) and may reduce mitral regurgitation by improving leaflet coaptation. It was hypothesized that therapeutic ultrasound (TU) from the ReCor (ReCor Inc., Ronkonkoma, NY, USA) device could result in such MA size reduction.
Background
Delivering energy at sub-ablative temperatures appears to produce contraction of the mitral valve annulus (MA) and may reduce mitral regurgitation by improving leaflet coaptation. It was hypothesized that therapeutic ultrasound (TU) from the ReCor (ReCor Inc., Ronkonkoma, NY, USA) device could result in such MA size reduction.
Methods
The ReCor device was studied in a closed chest procedure in a canine animal model. Under fluoroscopy, a 12-Fr TU balloon catheter (ReCor) was advanced to the left atrium (transeptal approach). The TU balloon (24 mm diameter) was inflated with contrast saline and positioned at the MA. TU energy (9 MHz) was delivered circumferentially. The TU balloon was applied against the posterior mitral annulus, and position was monitored through specific fluoroscopic and/or intracardiac US recordings. Five TU applications were delivered (up to 130 W for up to 120 s). Transthoracic echocardiogram and Doppler flow were obtained to measure the MA diameter (short and long axes) and mitral flow before, immediately after, and at 1, 2, 3, and 4 weeks after ablation.
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