Inferior Vena Cava Reconstruction in Living Donor Liver Transplantation



Fig. 12.1
For a satisfactory outflow reconstruction, the anterior wall of the vena cava and three hepatic veins are used to create a large orifice under cross-clamping of the vena cava



There are several patterns of venous reconstruction in LDLT mainly based on the graft type, and IVC should be prepared as such in accordance with the corresponding venous orifice of the graft. Most prevalent way of reconstruction is to anastomose between corresponding veins, meaning the stump of right hepatic vein (RHV) to graft RHV and the stump of MHV+ left hepatic vein (LHV) to graft MHV + LHV; however, to secure the enough width of orifice to prevent the outflow stenosis, meticulous efforts have been reported to extend and enlarge the orifice. To enlarge the orifice to the maximum extent, three hepatic veins should be opened continuously (Fig. 12.1b, c), and meanwhile, when it is too large, the orifice can be shortened by suturing the end of the orifice (right side for left-side graft and vice versa). To secure a good and safe surgical field in making one large orifice with all three hepatic veins, the cross-clamp on the suprahepatic vena cava should be placed as far cranial as possible (Fig. 12.1a), not placing the clamp beneath the hepatic veins with a partial clamp of IVC. Ligating and dividing the phrenic veins which are draining into the root of the confluence of hepatic veins on both sides of IVC allows the IVC to be safely cross-clamped on the cranial side (Fig. 12.2).

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Fig. 12.2
The phrenic veins draining into the inferior vena cava are ligated and divided to secure a wider space to cross-clamp the suprahepatic vena cava as cranial as possible



12.3 Outflow Reconstruction in LDLT


Besides the way to reconstruct each hepatic vein, there are several unsolved problems in the outflow reconstruction in LDLT, such as the inclusion of MHV in the right live graft [3], the reconstruction of MHV tributaries [4], and the reconstruction of short hepatic veins including inferior right hepatic vein (IRHV) [5]. However, it is widely accepted that the simple end-to-end anastomosis between corresponding hepatic veins is not sufficient to secure the adequate and long-lasting outflow drainage in LDLT recipients. Another important concern is the orthotopic position of the graft, especially in the left liver, and care should be taken for the graft position and anastomosis axis in outflow reconstruction not to hamper the outflow drainage. Accordingly, the venoplasty of both the recipient IVC and the graft veins is mandatory in the outflow reconstruction in LDLT.


12.3.1 Right Liver


The orifice of the recipient right hepatic vein is maximally extended caudally or to the left on IVC to provide for optimal graft outflow. There are several ways to enlarge the orifice of RHV on recipient IVC. One is to elongate RHV orifice toward caudal side, in which RHV is incised caudally with a patch plasty of the recipient RHV to remove the acute angle between RHV and IVC under the side clamp of IVC beneath the RHV, which was proposed by Asan group Korea [6]. In another way, IVC is divided horizontally for a distance corresponding to the transverse dimension of the orifice in the graft [7, 8]. The cranial and caudal flaps are excised so that a large triangular or oval opening is created and matched with that of the graft [9]. This method, which can be done with either partial clamp or cross-clamp of IVC, seems most prevalent worldwide. In these methods, MHV + LHV is closed in the preparation of IVC. Our current way, which is supposed to provide the maximum orifice, is to extend the incision to connect RHV and MHV + LHV, which usually provides the orifice 5–6 cm in diameter [10]. As described above, this procedure is most facilitated by placing the cross-clamp on the suprahepatic vena cava as far cranial as possible. It is important to recognize that graft regeneration causes the right liver graft to rotate axially from right to left, which will result in a possible kinking of anastomosis or the compression of the anastomosis [11]. In this aspect, it is important to achieve an anastomosis with enough reservoir capacity to tolerate any kind of axial kink or compression by graft regeneration or surrounding tissues, for which making a large orifice on IVC to the possible extent is utmost important in recipient operation. For this purpose, we use cryopreserved homologous venous patch on the left wall of RHV to cover the widely opened anterior wall of recipient IVC as a roof-like reservoir [10, 11] (Fig. 12.3). In the presence of MHV (the extended right liver graft) or reconstructed MHV tributaries (the modified right liver graft), venoplasty between MHV and RHV is commonly undergone on bench surgery to create a common orifice with RHV permitting a single anastomosis to recipient IVC [3].

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Fig. 12.3
A modified right liver graft. Schema of the reconstruction of middle hepatic vein tributaries (V5 and V8) with a cryopreserved homologous venous graft which was finally anastomosed to the widely opened inferior vena cava with an additional venous patch (a) and photos at bench surgery (b) and after outflow reconstruction and reperfusion in the recipient (c). RHV right hepatic vein, V5 drainage vein from segment V, V8 drainage vein from segment VIII


12.3.2 Left Liver


Unlike in right liver graft, outflow reconstruction in left liver is usually constructed between MHV + LHV on recipient IVC and the graft common orifice of MHV + LHV in end-to-end fashion [12]. However, it is also recommended as with the case in right liver to enlarge the orifice of the confluence of MHV and LHV in both the recipient IVC and the graft. First step is to unify LHV and MHV making an incision on the septum between MHV and LHV. Second, to enlarge the orifice further, the right wall of MHV is incised, and a venous patch is attached. The same patch procedure is usually needed in the graft [13, 14] (Fig. 12.4). This plasty of IVC can be accomplished with the partial clamping of IVC beneath the confluence of MHV + LHV; however, a larger orifice can be achieved by the same technique described in Sect. 12.2. We usually open recipient’s three hepatic veins continuously in left liver graft to achieve a maximal orifice on recipient IVC. When anastomosis is planned between thus widely opened anterior wall of IVC and the graft MHV + LHV which is generally short in height (2–5 mm), one certainly worries about tenting effect lifting the posterior wall of IVC upward resulting in a possible outflow block [15]. To avoid this phenomenon, a wall-like venous patch around MHV + LHV of the graft at the bench surgery to elongate the height and enlarge the orifice of MHV + LHV is mandatory [16].

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Fig. 12.4
A left liver graft with a caudate (Spiegel) lobe. Schematic view of the venoplasty with a circular cuff vein patch in the liver graft (a). Both sides of the orifices of the left and middle hepatic veins were cut to make them wider, around which the venous patch was attached, to make wide orifice with as circular cuff. A conduit vein graft was sutured between the short hepatic vein and left and middle hepatic veins. Photos at bench surgery (b, c)


12.4 Orthotopic Position of the Partial Graft


Caval drainage is one of the most important techniques in partial graft implantation. Not only the anastomosis but also the graft positioning can be important for the outflow. The graft should be placed in an orthotopic position, and care should be taken to consider the final position of the graft once the abdomen is closed. Especially for left liver grafts, it is important to fix the falciform ligament to the midline of the abdominal wall to prevent graft rotation to the right side. Hepatic outflow block is one of the major complications leading to severe graft dysfunction after LDLT. Left liver grafts are prone to pivoting around the IVC if the graft is not held tightly in its position by fixing the falciform ligament in the graft to the anterior abdominal wall. Rotation of the left liver graft to the vacant right subphrenic space after operation can result in a functional Budd–Chiari-like effect due to kinking of the venous anastomosis. Moreover, the left liver graft regenerates more aggressively than right liver which may cause the rotation of the graft toward the right and posterior side around the IVC axis. This again can cause kinks and outflow issues. In contrast, the right liver graft resides comfortably in the limited right subphrenic cavity and regenerates toward the left and anteromedial sides with little positional change of the venous anastomosis.


12.5 Reconstruction of Short Hepatic Veins


Relatively large short hepatic veins in right liver graft, so-called IRHV, and middle right hepatic vein (MRHV) and a caudate vein (draining Spiegel lobe) in left liver with Spiegel lobe should be reconstructed to expect the maximal graft function and regeneration. Of course, it is possible to anastomose these veins of the graft directly to the recipient IVC in an end-to-side fashion with a side clamping of IVC [5, 17]. In such instances, recipient IVC is incised which is corresponding to these veins of the graft. Direct anastomosis between the short hepatic vein and the recipient IVC is sometimes technically demanding. Because determining the optimal anastomotic site and direction is difficult and requires time, this may increase the warm ischemic time. To overcome these problems, we have recommended the reconstruction of these veins on the bench surgery, utilizing the cryopreserved homologous veins. In right liver graft with IRHV or MRHV, if the IVC graft is available, IRHV and MRHV can be reconstructed at the bench, which is called the double IVC method [10, 11] (Fig. 12.5). If the IVC graft is not available, but a thinner vein graft such as the femoral vein is available, similar reconstruction is possible [18] (Fig. 12.6). We must note that, in this case, extensive dissection of the IVC around the hepatic vein branches, including the phrenic veins, is unnecessary.

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Fig. 12.5
Double vena cava reconstruction in a right liver graft. Schema of the reconstruction of an extended right liver graft using the double vena cava technique with a cryopreserved homologous inferior vena cava (a). Photos at bench surgery (b) and after outflow reconstruction and reperfusion (c) in the recipient with the reconstruction of both middle hepatic vein tributaries and inferior right hepatic vein. RHV right hepatic vein, MHV middle hepatic vein, IRHV inferior right hepatic vein


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Fig. 12.6
Two ways to create the vena cava on the graft with thinner cryopreserved homologous veins. Two venous sheets are anastomosed either in the dorsal–ventral position (a) or in the left–right position (b) to create the alternative vena cava. (Liver Transpl 2005;11:101–103.) RHV right hepatic vein, MHV middle hepatic vein, MRHV middle right hepatic vein, IRHV inferior right hepatic vein, V5 drainage vein from segment V, V8 drainage vein from segment VIII, PV portal vein, A hepatic artery, B bile duct, SB superficial branch

In left liver graft, when a short hepatic vein and LHV + MHV are located close to each other, simple venoplasty at the bench is possible. Another option includes venoplasty using vein grafts at the bench. On the graft side, a wide venous orifice with a long cuff is formed by gathering the left, middle, and short hepatic veins using a conduit vein graft and patch vein grafts [14] (Fig. 12.4), which is then anastomosed to wide-opened recipient IVC.


12.6 Reconstruction of Middle Hepatic Vein Tributaries


When the right liver is harvested without MHV, the reconstruction of MHV tributaries, namely, V5 draining segment V and V8 draining segment VIII, should be considered. The indication for MHV tributary reconstruction should be determined preoperatively by measuring the drainage area volume of V5 and V8. If the uncongested area (i.e., area drained by the right hepatic vein) is sufficient for the metabolic demands of the recipient (usually 35–40 % of the recipient standard liver volume), reconstruction of the MHV tributaries is not necessary and vice versa [10].

MHV tributaries are usually reconstructed at the bench surgery with interposition vein grafts, such as autografts (recipient’s portal vein, hepatic vein, jugular vein, or iliac vein), cryopreserved venous or arterial grafts, and artificial grafts. The reconstructed MHV was anastomosed directly to recipient IVC in the initial report by Asan group [19]; however, nowadays venoplasty is usually performed between reconstructed MHV and RHV at bench surgery to create a common orifice with RHV which will allow a single anastomosis to recipient IVC (Fig. 12.3).


12.7 Grafts Used to Reconstruct IVC, Autograft, Allograft, Cryopreserved Allograft, and Artificial Graft


Numerous reports have been reported for the reconstruction of IVC and hepatic veins with various vein grafts. Internal jugular vein [20], femoral vein [21], portal vein (umbilical portion) [22, 23], and hepatic vein of the native liver [24] are frequently utilized as autografts taken from recipient himself. Allografts from the liver donor, such as round ligament [25], and femoral vein [26] can be another option, but the latter of which is not recommended in the consideration of donor priority. As described above, cryopreserved homologous veins from cardiac death donor are an optimal option for the venous reconstruction in LDLT [27, 28]. Artificial venous graft, polytetrafluoroethylene (PTFE), for venous reconstruction in LDLT is aggressively used in Asian high-volume center with promising results [29, 30], but may include potential disadvantage when compared to allo- or autografts [31]. In terms of patency, there seems no difference among these vein grafts [29]. Advantages and disadvantages are summarized in Table 12.1.
Oct 14, 2017 | Posted by in CARDIOLOGY | Comments Off on Inferior Vena Cava Reconstruction in Living Donor Liver Transplantation

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