Objectives .– To assess LV myocardial deformation with 3D echocardiography in HCM and study the impact of hypertrophy on global and regional systolic deformation.
Patients and methods .– A complete rest echocardiography (GE Vivid 9) was performed in 41 HCM and in 114 control patients. Secondary HCM were excluded. LV systolic deformation was assessed by 3D strains. Values of 3D global LV longitudinal (3DGLS), circumferential (3DGCS), radial (3DRS) and area strain (3DGAS) were obtained from all patients. We classified segments depending on their thickness as first quartile (< 105 mm, n = 157), second quartile (105–131 mm, n = 152), third quartile (131–166 mm, n = 162) and fourth quartile (> 166 mm, n = 165).
Results .– All strain values were significantly higher in control than in HCM pts. There was a significant decrease from second quartile to fourth quartile ( P < 0.05), gradually for longitudinal then radial and circumferential strain values ( Table 1 ).
| < 105 mm segments n = 157 | 105–131 mm segments n = 152 | 131–166 mm segments n = 162 | > 166 mm segments n = 165 | HCM patients n = 41 | Controls subjects n = 114 | |
|---|---|---|---|---|---|---|
| Age (years) | 56.6 ± 1 13.5 | 54.9 ± 12.0 | ||||
| LVEF (%) | 62.3 ± 7.1 | 62.6 ± 4.4 | ||||
| 3D GAS (%) | −29.4 ± 10.7 | −27.3 ± 9.5 a | −23.5 ± 110.4 b | −20.5 ± 7.1 c | −25.0 ± 10 d | −34.8 ± 3.2 |
| 3DGLS (%) | −14.6 ± 8.5 | −12.6 ± 17.8 a | −9.8 ± 8.1 b | −7.5 ± 7.1 c | −11.2 ± 17.7 d | −20.3 ± 2.7 |
| 3DGCS (%) | −18.6 ± 6.5 | −17.9 ± 6.7 a | −16.2 ± 7.0 b | −14.8 ± 6.5 c | −16.8 ± 6.9 d | 18.7 ± 2.9 |
| 3DGRS (%) | 47.31 ± 21.7 | 42.0 ± 19 a | 35.4 ± 19.5 b | 28.4 ± 14.9 c | 38.3 ± 20 d | 54.6 ± 9.0 |
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