ECG characteristics:

Etiology:

• Genetic defect in chromosome 1, 11, 14, or 15; encoding of pathological myofibrils

ECG characteristics:

• Often highly positive Sokolow index (see 5.1 Left Ventricular Hypertrophy)
  
• Marked T inversion in the precordial leads (pseudo-infarction ECG)

Mechanism:

• Hypertrophy-related relative ischemia of the inner layer causing disturbance of repolarization in this region, flow of current from outer to inner layer

Obstruction:

• LVOT, apical, midseptal
  
• No obstruction (HNCM)

Treatment:

• Beta-blocker, calcium antagonists (verapamil)
  
• Pacemaker
  
• Interventional sclerosis of septal branch (TASH), operative intervention (myectomy)
  
• Arrhythmia prophylaxis (amiodarone)
  
• Insertion of debrillator with occurrence of malignant ventricular arrhythmias