Reused with permission. From Hansell DM, Bankier AA, MacMahon H, et al. Fleischner Society: Glossary of terms for thoracic imaging Radiology. 2008 Mar; 246(3):697–772. Epub 2008 Jan 14. © RSNA, 2008
David M. Hansell, MD, FRCP, FRCR
Alexander A. Bankier, MD
Heber MacMahon, MB, BCh, BAO
Theresa C. McLoud, MD
Nestor L. Müller, MD, PhD
Jacques Remy, MD
© RSNA, 2008
Published online before print 10.1148/radiol.2462070712
Radiology 2008; 246:697–722
Authors stated no financial relationship to disclose.
1 From the Department of Radiology, Royal Brompton Hospital, Sydney Street, London SW3 6NP, United Kingdom (D.M.H.); Department of Radiology, Beth Israel Deaconess Medical Center, Boston, Mass (A.A.B.); Department of Radiology, University of Chicago Hospital, Chicago, Ill (H.M.); Department of Radiology, Massachusetts General Hospital, Boston, Mass (T.C.M.); Department of Radiology, Vancouver General Hospital, Vancouver, British Columbia, Canada (N.L.M.); and Department of Radiology, CHRU de Lille, Hôpital Calmette, Lille, France (J.R.). Received April 21, 2007; revision requested May 29; revision received June 6; accepted August 7; final version accepted September 19. Address correspondence to: D.M.H. (e-mail: email@example.com ).The present glossary is the third prepared by members of the Fleischner Society and replaces the glossaries of terms for thoracic radiology and CT , respectively. The impetus to combine and update the previous versions came from the recognition that with the recent developments in imaging new words have arrived, others have become obsolete, and the meaning of some terms has changed. The intention of this latest glossary is not to be exhaustive but to concentrate on those terms whose meaning may be problematic. Terms and techniques not used exclusively in thoracic imaging are not included.
Two new features are the inclusion of brief descriptions of the idiopathic interstitial pneumonias (IIPs) and pictorial examples (chest radiographs and computed tomographic [CT] scans) for the majority of terms. The decision to include vignettes of the IIPs (but not other pathologic entities) was based on the perception that, despite the recent scrutiny and reclassification, the IIPs remain a confusing group of diseases. We trust that the illustrations enhance, but do not distract from, the definitions. In this context, the figures should be regarded as of less importance than the text—they are merely examples and should not be taken as representing the full range of possible imaging appearances (which may be found in the references provided in this glossary or in comprehensive textbooks).
We hope that this glossary of terms will be helpful, and it is presented in the spirit of the sentiment of Edward J. Huth that “scientific writing calls for precision as much in naming things and concepts as in presenting data.” It is right to repeat the request with which the last Fleischner Society glossary closed: “[U]se of words is inherently controversial and we are pleased to invite readers to offer improvements to our definitions.”
Anatomy. The acinus is a structural unit of the lung distal to a terminal bronchiole and is supplied by first-order respiratory bronchioles; it contains alveolar ducts and alveoli. It is the largest unit in which all airways participate in gas exchange and is approximately 6-10 mm in diameter. One secondary pulmonary lobule contains between three and 25 acini .
Radiographs and CT scans. Individual normal acini are not visible, but acinar arteries can occasionally be identified on thin-section CT scans. Accumulation of pathologic material in acini may be seen as poorly defined nodular opacities on chest radiographs and thin-section CT images. (See also nodules. )
acute interstitial pneumonia, or AIP:
Pathology. The term acute interstitial pneumonia is reserved for diffuse alveolar damage of unknown cause. The acute phase is characterized by edema and hyaline membrane formation. The later phase is characterized by airspace and/or interstitial organization . The histologic pattern is indistinguishable from that of acute respiratory distress syndrome.
Radiographs and CT scans. In the acute phase, patchy bilateral ground-glass opacities are seen , often with some sparing of individual lobules, producing a geographic appearance; dense opacification is seen in the dependent lung ( Fig 1 ). In the organizing phase, architectural distortion, traction bronchiectasis, cysts, and reticular opacities are seen .
Radiographs and CT scans. An air bronchogram is a pattern of air-filled (low-attenuation) bronchi on a background of opaque (high-attenuation) airless lung ( Fig 2 ). The sign implies (a) patency of proximal airways and (b) evacuation of alveolar air by means of absorption (atelectasis) or replacement (e.g., pneumonia) or a combination of these processes. In rare cases, the displacement of air is the result of marked interstitial expansion (e.g., lymphoma) .
Radiographs and CT scans. An air crescent is a collection of air in a crescentic shape that separates the wall of a cavity from an inner mass ( Fig 3 ). The air crescent sign is often considered characteristic of either Aspergillus colonization of preexisting cavities or retraction of infarcted lung in angioinvasive aspergillosis . However, the air crescent sign has also been reported in other conditions, including tuberculosis, Wegener granulomatosis, intracavitary hemorrhage, and lung cancer. (See also mycetoma. )
Pathophysiology. Air trapping is retention of air in the lung distal to an obstruction (usually partial).
CT scans. Air trapping is seen on end-expiration CT scans as parenchymal areas with less than normal increase in attenuation and lack of volume reduction. Comparison between inspiratory and expiratory CT scans can be helpful when air trapping is subtle or diffuse ( Fig 4 ). Differentiation from areas of decreased attenuation resulting from hypoperfusion as a consequence of an occlusive vascular disorder (e.g., chronic thromboembolism) may be problematic , but other findings of airway versus vascular disease are usually present. (See also mosaic attenuation pattern. )
Anatomy. An airspace is the gas-containing part of the lung, including the respiratory bronchioles but excluding purely conducting airways, such as terminal bronchioles.
Radiographs and CT scans. This term is used in conjunction with consolidation, opacity, and nodules to designate the filling of airspaces with the products of disease .
Anatomy. The aortopulmonary window is the mediastinal region bounded anteriorly by the ascending aorta, posteriorly by the descending aorta, cranially by the aortic arch, inferiorly by the left pulmonary artery, medially by the ligamentum arteriosum, and laterally by the pleura and left lung .
Radiographs and CT scans. Focal concavity in the left mediastinal border below the aorta and above the left pulmonary artery can be seen on a frontal radiograph ( Fig 5 ). Its appearance may be modified by tortuosity of the aorta. The aortopulmonary window is a common site of lymphadenopathy in a variety of inflammatory and neoplastic diseases.
Pathology. An apical cap is a caplike lesion at the lung apex, usually caused by intrapulmonary and pleural fibrosis pulling down extrapleural fat or possibly by chronic ischemia resulting in hyaline plaque formation on the visceral pleura . The prevalence increases with age. It can also be seen in hematoma resulting from aortic rupture or in other fluid collection associated with infection or tumor, either outside the parietal pleura or loculated within the pleural space .
Radiographs and CT scans. The usual appearance is of homogeneous soft-tissue attenuation capping the extreme lung apex (uni- or bilaterally), with a sharp or irregular lower border ( Fig 6 ). Thickness is variable, ranging up to about 30 mm . An apical cap occasionally mimics apical consolidation on transverse CT scans.
Pathology. Architectural distortion is characterized by abnormal displacement of bronchi, vessels, fissures, or septa caused by diffuse or localized lung disease, particularly interstitial fibrosis.
CT scans. Lung anatomy has a distorted appearance and is usually associated with pulmonary fibrosis ( Fig 7 ) and accompanied by volume loss.
Pathophysiology. Atelectasis is reduced inflation of all or part of the lung . One of the commonest mechanisms is resorption of air distal to airway obstruction (e.g., an endobronchial neoplasm) . The synonym collapse is often used interchangeably with atelectasis, particularly when it is severe or accompanied by obvious increase in lung opacity.
Radiographs and CT scans. Reduced volume is seen, accompanied by increased opacity (chest radiograph) or attenuation (CT scan) in the affected part of the lung ( Fig 8 ). Atelectasis is often associated with abnormal displacement of fissures, bronchi, vessels, diaphragm, heart, or mediastinum . The distribution can be lobar, segmental, or subsegmental. Atelectasis is often qualified by descriptors such as linear, discoid, or platelike. (See also linear atelectasis, rounded atelectasis. )
Anatomy. The azygoesophageal recess is a right posterior mediastinal recess into which the edge of the right lower lobe extends. It is limited superiorly by the azygos arch, posteriorly by the azygos vein and pleura anterior to the vertebral column, and medially by the esophagus and adjacent structures.
Radiographs and CT scans. On a frontal chest radiograph, the recess is seen as a vertically oriented interface between the right lower lobe and the adjacent mediastinum (the medial limit of the recess). Superiorly, the interface is seen as a smooth arc with convexity to the left. Disappearance or distortion of part of the interface suggests disease (e.g., subcarinal lymphadenopathy). On CT scans, the recess ( Fig 9 ) merits attention because small lesions located in the recess will often be invisible on chest radiographs .
azygos fissure: See fissure.
beaded septum sign:
CT scans. This sign consists of irregular and nodular thickening of interlobular septa reminiscent of a row of beads ( Fig 10 ). It is frequently seen in lymphangitic spread of cancer and less often in sarcoidosis .
Anatomy. A bleb is a small gas-containing space within the visceral pleura or in the subpleural lung, not larger than 1 cm in diameter .
CT scans. A bleb appears as a thin-walled cystic air space contiguous with the pleura. Because the arbitrary (size) distinction between a bleb and bulla is of little clinical importance, the use of this term by radiologists is discouraged.
Pathology. Bronchiectasis is irreversible localized or diffuse bronchial dilatation, usually resulting from chronic infection, proximal airway obstruction, or congenital bronchial abnormality . (See also traction bronchiectasis. )
Radiographs and CT scans. Morphologic criteria on thin-section CT scans include bronchial dilatation with respect to the accompanying pulmonary artery (signet ring sign), lack of tapering of bronchi, and identification of bronchi within 1 cm of the pleural surface ( Fig 11 ). Bronchiectasis may be classified as cylindric, varicose, or cystic, depending on the appearance of the affected bronchi. It is often accompanied by bronchial wall thickening, mucoid impaction, and small-airways abnormalities . (See also signet ring sign. )
Anatomy. Bronchioles are non–cartilage-containing airways. Terminal bronchioles are the most distal of the purely conducting airways; they give rise to respiratory bronchioles, from which the alveoli arise and permit gas exchange. Respiratory bronchioles branch into multiple alveolar ducts .
Radiographs and CT scans. Bronchioles are not identifiable in healthy individuals, because the bronchiolar walls are too thin . In inflammatory small-airways disease, however, thickened or plugged bronchioles may be seen as a nodular pattern on a chest radiograph or as a tree-in-bud pattern on CT scans.
Pathology. Bronchiolectasis is defined as dilatation of bronchioles. It is caused by inflammatory airways disease (potentially reversible) or, more frequently, fibrosis.
CT scans. When dilated bronchioles are filled with exudate and are thick walled, they are visible as a tree-in-bud pattern or as centrilobular nodules . In traction bronchiolectasis, the dilated bronchioles are seen as small, cystic, tubular airspaces, associated with CT findings of fibrosis ( Fig 12 ). (See also traction bronchiectasis and traction bronchiolectasis, tree-in-bud pattern. )
Pathology. Bronchiolitis is bronchiolar inflammation of various causes .
CT scans. This direct sign of bronchiolar inflammation (e.g., infectious cause) is most often seen as the tree-in-bud pattern, centrilobular nodules, and bronchiolar wall thickening on CT scans. (See also small-airways disease, tree-in-bud pattern. )
Pathology. A bronchocele is bronchial dilatation due to retained secretions (mucoid impaction) usually caused by proximal obstruction, either congenital (e.g., bronchial atresia) or acquired (e.g., obstructing cancer) .
Radiographs and CT scans. A bronchocele is a tubular or branching Y – or V -shaped structure that may resemble a gloved finger ( Fig 13 ). The CT attenuation of the mucus is generally that of soft tissue but may be modified by its composition (e.g., high-attenuation material in allergic bronchopulmonary aspergillosis). In the case of bronchial atresia, the surrounding lung may be of decreased attenuation because of reduced ventilation and, thus, perfusion.
CT scans. This descriptor is applied to disease that is conspicuously centered on macroscopic bronchovascular bundles ( Fig 14 ). Examples of diseases with a bronchocentric distribution include sarcoidosis , Kaposi sarcoma , and organizing pneumonia .
Pathology. A broncholith, a calcified peribronchial lymph node that erodes into an adjacent bronchus, is most often the consequence of Histoplasma or tuberculous infection.
Radiographs and CT scans. The imaging appearance is of a small calcific focus in or immediately adjacent to an airway ( Fig 15 ), most frequently the right middle lobe bronchus. Broncholiths are readily identified on CT scans . Distal obstructive changes may include atelectasis, mucoid impaction, and bronchiectasis.
Pathology. An airspace measuring more than 1 cm—usually several centimeters—in diameter, sharply demarcated by a thin wall that is no greater than 1 mm in thickness. A bulla is usually accompanied by emphysematous changes in the adjacent lung. (See also bullous emphysema. )
Radiographs and CT scans. A bulla appears as a rounded focal lucency or area of decreased attenuation, 1 cm or more in diameter, bounded by a thin wall ( Fig 16 ). Multiple bullae are often present and are associated with other signs of pulmonary emphysema (centrilobular and paraseptal).
Pathology. Bullous emphysema is bullous destruction of the lung parenchyma, usually on a background of paraseptal or panacinar emphysema. (See also emphysema, bulla. )
Radiographs and CT scans. A cavity is a gas-filled space, seen as a lucency or low-attenuation area, within pulmonary consolidation, a mass, or a nodule ( Fig 17 ). In the case of cavitating consolidation, the original consolidation may resolve and leave only a thin wall. A cavity is usually produced by the expulsion or drainage of a necrotic part of the lesion via the bronchial tree. It sometimes contains a fluid level. Cavity is not a synonym for abscess.
Anatomy. Centrilobular describes the region of the bronchiolovascular core of a secondary pulmonary lobule . This term is also used by pathologists to describe the location of lesions beyond the terminal bronchiole that center on respiratory bronchioles or even alveolar ducts.
CT scans. A small dotlike or linear opacity in the center of a normal secondary pulmonary lobule, most obvious within 1 cm of a pleural surface, represents the intralobular artery (approximately 1 mm in diameter) . Centrilobular abnormalities include (a) nodules, (b) a tree-in-bud pattern indicating small-airways disease, (c) increased visibility of centrilobular structures due to thickening or infiltration of the adjacent interstitium, or (d) abnormal areas of low attenuation caused by centrilobular emphysema . (See also lobular core structures. )
Pathology. Centrilobular emphysema is characterized by destroyed centrilobular alveolar walls and enlargement of respiratory bronchioles and associated alveoli . This is the commonest form of emphysema in cigarette smokers.
CT scans. CT findings are centrilobular areas of decreased attenuation, usually without visible walls, of nonuniform distribution and predominantly located in upper lung zones ( Fig 18 ). The term centriacinar emphysema is synonymous. (See also emphysema. )
collapse: See atelectasis.
Pathology. Consolidation refers to an exudate or other product of disease that replaces alveolar air, rendering the lung solid (as in infective pneumonia).
Radiographs and CT scans. Consolidation appears as a homogeneous increase in pulmonary parenchymal attenuation that obscures the margins of vessels and airway walls ( Fig 19 ). An air bronchogram may be present. The attenuation characteristics of consolidated lung are only rarely helpful in differential diagnosis (e.g., decreased attenuation in lipoid pneumonia and increased in amiodarone toxicity ).
CT scans. This pattern appears as thickened interlobular septa and intralobular lines superimposed on a background of ground-glass opacity ( Fig 20 ), resembling irregularly shaped paving stones. The crazy-paving pattern is often sharply demarcated from more normal lung and may have a geographic outline. It was originally reported in patients with alveolar proteinosis and is also encountered in other diffuse lung diseases that affect both the interstitial and airspace compartments, such as lipoid pneumonia .
cryptogenic organizing pneumonia, or COP: See organizing pneumonia.
Pathology. A cyst is any round circumscribed space that is surrounded by an epithelial or fibrous wall of variable thickness .
Radiographs and CT scans. A cyst appears as a round parenchymal lucency or low-attenuating area with a well-defined interface with normal lung. Cysts have variable wall thickness but are usually thin-walled (<2 mm) and occur without associated pulmonary emphysema ( Fig 21 ). Cysts in the lung usually contain air but occasionally contain fluid or solid material. The term is often used to describe enlarged thin-walled airspaces in patients with lymphangioleiomyomatosis or Langerhans cell histiocytosis ; thicker-walled honeycomb cysts are seen in patients with end-stage fibrosis . (See also bleb, bulla, honeycombing, pneumatocele. )
desquamative interstitial pneumonia, or DIP:
Pathology. Histologically, DIP is characterized by the widespread accumulation of an excess of macrophages in the distal airspaces. The macrophages are uniformly distributed, unlike in respiratory bronchiolitis–interstitial lung disease, in which the disease is conspicuously bronchiolocentric. Interstitial involvement is minimal. Most cases of DIP are related to cigarette smoking, but a few are idiopathic or associated with rare inborn errors of metabolism .
Radiographs and CT scans. Ground-glass opacity is the dominant abnormality and tends to have a basal and peripheral distribution ( Fig 22 ). Microcystic or honeycomb changes in the area of ground-glass opacity are seen in some cases .
diffuse alveolar damage, or DAD: See acute interstitial pneumonia.
Pathology. Emphysema is characterized by permanently enlarged airspaces distal to the terminal bronchiole with destruction of alveolar walls . Absence of “obvious fibrosis” was historically regarded as an additional criterion , but the validity of that criterion has been questioned because some interstitial fibrosis may be present in emphysema secondary to cigarette smoking . Emphysema is usually classified in terms of the part of the acinus predominantly affected: proximal (centriacinar, more commonly termed centrilobular, emphysema), distal (paraseptal emphysema), or whole acinus (panacinar or, less commonly, panlobular emphysema).
CT scans. The CT appearance of emphysema consists of focal areas or regions of low attenuation, usually without visible walls . In the case of panacinar emphysema, decreased attenuation is more diffuse. (See also bullous emphysema, centrilobular emphysema, panacinar emphysema, paraseptal emphysema. )
Anatomy. A fissure is the infolding of visceral pleura that separates one lobe or part of a lobe from another; thus, the interlobar fissures are produced by two layers of visceral pleura. Supernumerary fissures usually separate segments rather than lobes. The azygos fissure, unlike the other fissures, is formed by two layers each of visceral and parietal pleura. All fissures (apart from the azygos fissure) may be incomplete.
Radiographs and CT scans. Fissures appear as linear opacities, normally 1 mm or less in thickness, that correspond in position and extent to the anatomic fissural separation of pulmonary lobes or segments. Qualifiers include minor, major, horizontal, oblique, accessory, anomalous, azygos, and inferior accessory.
folded lung: See rounded atelectasis.
fungus ball: See mycetoma.
gas trapping: See air trapping.
ground-glass nodule: See nodule.
Radiographs and CT scans. On chest radiographs, ground-glass opacity appears as an area of hazy increased lung opacity, usually extensive, within which margins of pulmonary vessels may be indistinct. On CT scans, it appears as hazy increased opacity of lung, with preservation of bronchial and vascular margins ( Fig 23 ). It is caused by partial filling of airspaces, interstitial thickening (due to fluid, cells, and/or fibrosis), partial collapse of alveoli, increased capillary blood volume, or a combination of these, the common factor being the partial displacement of air . Ground-glass opacity is less opaque than consolidation, in which bronchovascular margins are obscured. (See also consolidation. )
CT scans. The halo sign is a CT finding of ground-glass opacity surrounding a nodule or mass ( Fig 24 ). It was first described as a sign of hemorrhage around foci of invasive aspergillosis . The halo sign is nonspecific and may also be caused by hemorrhage associated with other types of nodules or by local pulmonary infiltration by neoplasm (e.g., adenocarcinoma). (See also reversed halo sign. )
Anatomy. Hilum is a generic term that describes the indentation in the surface of an organ, where vessels and nerves connect with the organ. It is the site on the medial aspect of the lung where the vessels and bronchi enter and leave the lung.
Radiographs and CT scans. A hilum appears as a composite opacity at the root of each lung produced by bronchi, arteries, veins, lymph nodes, nerves, and other tissue. The terms hilum (singular) and hila (plural) are preferred to hilus and hili respectively; the adjectival form is hilar.
Pathology. Honeycombing represents destroyed and fibrotic lung tissue containing numerous cystic airspaces with thick fibrous walls, representing the late stage of various lung diseases, with complete loss of acinar architecture. The cysts range in size from a few millimeters to several centimeters in diameter, have variable wall thickness, and are lined by metaplastic bronchiolar epithelium .
Radiographs and CT scans. On chest radiographs, honeycombing appears as closely approximated ring shadows, typically 3–10 mm in diameter with walls 1–3 mm in thickness, that resemble a honeycomb; the finding implies end-stage lung disease. On CT scans, the appearance is of clustered cystic air spaces, typically of comparable diameters on the order of 3–10 mm but occasionally as large as 2.5 cm ( Fig 25 ). Honeycombing is usually subpleural and is characterized by well-defined walls . It is a CT feature of established pulmonary fibrosis . Because honeycombing is often considered specific for pulmonary fibrosis and is an important criterion in the diagnosis of usual interstitial pneumonia , the term should be used with care, as it may directly impact patient care.
idiopathic pulmonary fibrosis:
Pathology. Idiopathic pulmonary fibrosis is a specific form of chronic fibrosing interstitial pneumonia of unknown cause and is characterized by a histologic pattern of usual interstitial pneumonia .
Radiographs and CT scans. The typical imaging findings are reticular opacities and honeycombing, with a predominantly peripheral and basal distribution ( Fig 26 ). Ground-glass opacity, if present, is less extensive than reticular and honeycombing patterns. The typical radiologic findings are also encountered in usual interstitial pneumonia secondary to specific causes, such as asbestos-induced pulmonary fibrosis (asbestosis), and the diagnosis is usually one of exclusion. (See also usual interstitial pneumonia. )
Pathology. Infarction is a process that may result in ischemic necrosis, usually the consequence of vascular compromise such as occlusion of a feeding pulmonary artery by an embolus (venous infarction is rare but recognized). Necrosis is relatively uncommon because tissue viability is maintained by the bronchial arterial blood supply. Pulmonary infarction may be secondary to a vasculitis (e.g., Wegener granulomatosis).
Radiographs and CT scans. A pulmonary infarct is typically triangular or dome-shaped, with the base abutting the pleura and the apex directed toward the hilum ( Fig 27 ). The opacity represents local hemorrhage with or without central tissue necrosis .
Radiographs and CT scans. Formerly used as a term to describe a region of pulmonary opacification caused by airspace or interstitial disease seen on radiographs and CT scans. Infiltrate remains controversial because it means different things to different people . The term is no longer recommended, and has been largely replaced by other descriptors. The term opacity, with relevant qualifiers, is preferred.
interlobular septal thickening:
Radiographs and CT scans. This finding is seen on chest radiographs as thin linear opacities at right angles to and in contact with the lateral pleural surfaces near the lung bases (Kerley B lines); it is seen most frequently in lymphangitic spread of cancer or pulmonary edema. Kerley A lines are predominantly situated in the upper lobes, are 2–6 cm long, and can be seen as fine lines radially oriented toward the hila. In recent years, the anatomically descriptive terms septal lines and septal thickening have gained favor over Kerley lines. On CT scans, disease affecting one of the components of the septa (see interlobular septum ) may be responsible for thickening and so render septa visible. On thin-section CT scans, septal thickening may be smooth or nodular ( Fig 28 ), which may help refine the differential diagnosis. (See also interlobular septum, beaded septum. )
Anatomy. Interlobular septa are sheetlike structures 10–20 mm long that form the borders of lobules; they are more or less perpendicular to the pleura in the periphery. Interlobular septa are composed of connective tissue and contain lymphatic vessels and pulmonary venules.
Radiographs and CT scans. Interlobular septa appear as thin linear opacities between lobules ( Fig 29 ); these septa are to be distinguished from centrilobular structures. They are not usually seen in the healthy lung (normal septa are approximately 0.1 mm thick) but are clearly visible when thickened (e.g., by pulmonary edema). (See also interlobular septal thickening, lobule. )
Pathology. Interstitial emphysema is characterized by air dissecting within the interstitium of the lung, typically in the peribronchovascular sheaths, interlobular septa, and visceral pleura. It is most commonly seen in neonates receiving mechanical ventilation.
Radiographs and CT scans. Interstitial emphysema is rarely recognized radiographically in adults and is infrequently seen on CT scans ( Fig 30 ). It appears as perivascular lucent or low-attenuating halos and small cysts .
Anatomy. The interstitium consists of a continuum of connective tissue throughout the lung comprising three subdivisions: (a) the bronchovascular (axial) interstitium, surrounding and supporting the bronchi, arteries, and veins from the hilum to the level of the respiratory bronchiole; (b) the parenchymal (acinar) interstitium, situated between alveolar and capillary basement membranes; and (c) the subpleural connective tissue contiguous with the interlobular septa .
CT scans. Intralobular lines are visible as fine linear opacities in a lobule when the intralobular interstitial tissue is abnormally thickened ( Fig 31 ). When numerous, they may appear as a fine reticular pattern. Intralobular lines may be seen in various conditions, including interstitial fibrosis and alveolar proteinosis .