, George B. Kuzycz3 and Raymond A. DieterIII4
(1)
Northwestern Medicine, At Central DuPage Hospital, Winfield, IL, USA
(2)
International College of Surgeons, Cardiothoracic and Vascular Surgery, Glen Ellyn, IL, USA
(3)
Thoracic and Cardiovascular Surgery, Cadence Hospital of Northwestern System, Winfield, IL 60190, USA
(4)
Division of Cardiothoracic Surgery, The University of Tennessee Medical Center, Knoxville, TN 37920, USA
Keywords
AmputationTransplantationReplantationViabilityFunctionalitySevered extremityHand replantationHand transplantLeg replantationMajor traumatic episodes usually involve the chest and abdomen. As such, many of these result in death or prolonged recovery periods prior to rehabilitation of the individual. Concomitant to these torso and head injuries, extremity trauma may also occur simultaneously. When such injuries do take place, the orthopedists are usually consulted to manage the injured arm or leg fracture or soft tissue “injury.”
We have seen a number of these major traumatized individuals for treatment of their crushed, devascularized, or, even, transected extremity. Usually, when the lesion is more central, we have been requested to consult and to provide patient care. But when the injury involves the digits or hand, the hand surgeon or orthopedist has been the primary responsible operating surgeon. Whether the injury is proximal—near the trunk—or distal and involving the hand or foot, care of the patient and the traumatized or amputated tissue is a major surgical and postsurgical medical care project. Certainly, amputation may be the ultimate result in extremity ischemia.
In our experience, the most difficult patients to treat and care for are those who have a major crush injury . These injuries cause tissue trauma that many times are beyond salvage. The tissue is crushed and macerated and lacks reconstructionable or usable potentially viable structures for salvage and preservation of the arm, leg, and the individual. This is most apparent when a portion of the torso is also involved in these major crush injuries. Frequently, the combination of extremity and torso injuries has made debridement, resection, and replantation in these patients virtually impossible. Most of these incidents have been seen with garbage truck, fork lift, and similar heavy crushing machinery.
The type of injury most amenable to surgical reconstruction usually is the sharper more “clean-cut” injury with little adjacent tissue damage. Accidents which provide knife-like transection of tissue allow the surgeon to more readily locate, identify, debride, and then properly anastomose the involved tissues. These situations lend themselves to a greater chance of a functional and viable extremity or portion of an extremity then with the crushing or crush-amputation injury .
History
Historically, the amputated fingertip, distal phalanx, or the entire digit was the first to be replanted. With the advent of microsurgery 50 years ago, the reattachment success rate was increased and thus the salvage rate improved. Function and sensation were enhanced with restoration of circulation (arterial and venous), bone stabilization, tendon repair, nerve connection, and skin closure. Attention to the preoperative, operative, and postoperative care has all led to improved function [1].
Simultaneously, larger amputated structures were being replanted in an effort to provide a functional and viable arm or leg. In the early 1960s, replantation of the arm was attempted and accomplished by a number of surgical programs throughout the USA. In January 1963, a 15-year-old Eskimo male accidentally caused the amputation of his right arm just below the shoulder while playing a game with friends using a commercial washing machine. The arm had been amputated just below the shoulder, due to the rotary motion of the machine. Feeling he would bleed massively, all automobile speed limits were broken by me when the ER nurse contacted me. On my arrival, the boy was reading a comic book in no distress at the nurse’s desk. Ten minutes later another boy brought the arm wrapped in a towel to me at the hospital outpatient clinic. After laboratory, blood typing, proper surgical preparation, and repair of the nasal injuries while using a pHisoHex prep, the mangled arm was reattached focusing primarily on the vascular supply. Following several hours of surgery, we then elected to remove the arm due to its condition and close the upper arm stump approximately 4–6 inches below the shoulder. Later, after consultation with other centers, the consensus was that the brachial plexus twisting and avulsion along with the mangled multiply fractured distal arm wounds incurred by the arm would not have allowed function in the future, even if viable, and that no replantation and that arm removal was the best option. His wounds healed well and he was referred for outpatient physical therapy and rehabilitation.
Unfortunately, functionality of these extremities was and remains a major concern for the treating physician and the patient. Viability did not guarantee usability of the replanted extremity nor was the patient free from complications and further health risks. Later, when Professor Harold Haley and I attended a trauma meeting in San Antonio, two patients were presented. One had an upper arm amputation without replantation. He was happy, outgoing, and employed. The other had a surviving upper arm replantation without return of function. He was depressed, withdrawn, and not working—thus a concern as to whether the arm should have been reattached was expressed.
Some time later, we then encountered the near-total amputation of a leg except for a few inches of skin. He represents a viable replant but with minimal function. After reconstructive boney, muscular, vascular, and neural component surgery, his leg was viable. But a decade later, he requested amputation of the near-functionless but viable extremity due to multiple problems, including infection, with the replanted extremity.
Initial Trauma Care
With experience over the years, physicians and surgeons learned more about the multiple aspects of extremity amputation and salvage reattachment. The factors concerning preoperative preparation, surgery, and postsurgical care all became of importance if one wished to salvage the amputated extremity or a part thereof of the body Table 54.1.
Table 54.1
Factors influencing survival of an amputated extremity
Site of accident |
Type of injury |
Location of injury |
Condition of individual |
Condition of amputated structure |
Preop management |
Cleanliness |
Antibiotics |
Stability of patient |
Ancillary injuries |
Operative management |
Anesthetic |
Tissue condition |
Surgical repair |
Maintenance of vitals |
Postoperative care |
Maintenance of vitals |
Possible ICU |
Stabilization of patient and extremity |
Monitoring extremity |
Factors influencing survival of an amputated extremity |
Antibiotic consideration |
Protection of reimplanted denervated amputated tissue |
Long-term care |
Patient participation |
Rehabilitation program |
As listed above, a number of factors concerning the incident, its location, the cause, and the condition of the injured patient are all relevant to the possible salvage and replantation of an extremity. Obviously, the part amputated must be salvageable and potentially viable without undue risk of life while obtaining a viable replant. The harmed individual must be potentially salvageable and transportable to a facility where the amputated part and amputee may receive appropriate care without undue delay. Infection potential and time delay must be managed appropriately and safely.
At the treating facility, evaluation of the tissue for crush, mangling, or inappropriate contamination with infectious or noxious agents will be performed. Antibiotic and resuscitation steps will be initiated. Simultaneously, determination as to the patient’s acute and possibly chronic health condition will be taken into consideration. Checking for other major ancillary injuries will be important—especially of the cranial, thoracic, and abdominopelvic organs. Cleanliness and patient temperature concerns will be important determinants in the decision process.
In surgery , appropriate anesthesia and multisystem monitoring will be maintained before, during, and after the reattachment. Blood loss, body and extremity temperature, heart rate, and urine volume will require consideration. Certainly the ability to locate and label appropriate structures will require adequate time after boney stabilization. Tendon, neural, and vascular (venous and arterial) anastomoses will follow with appropriate identification and surgical techniques [1]. The closure of skin over the exposed structures without tension will aid in tissue survival and avoidance of infection. All of this care will require a long period of anesthesia, maintenance of vitals, and multiple personnel—including surgical specialties or subspecialties.
Postoperatively , depending on the condition of the patient and the amputated structure, the use of the intensive care facilities and staff may be necessary. Laboratory, vital signs, and patient-extremity monitoring will all be of value. Complete blood count (CBC), electrolyte, x-ray, and urine volume will be followed as appropriate. Patient alertness and responsiveness will affect one’s evaluation as well as color and temperature of the amputated tissue replanted. With time, dietary and ambulatory options will be advanced. With more stabilization, short-term physical and occupational rehab programs will be initiated and the longer programs introduced. Reasonable early onset of such programs will aide in the eventual rehab of the patient.
Personnel Involvement
As presented above, the number and type of personnel involved in the patient’s care vary from the local accident scene to the long-term post-discharge rehab staff. At the scene of the trauma, there may be only the patient, a few bystanders, or a crowd. Many times the paramedics or emergency personnel will arrive at the scene and monitor the situation. With our first patient, he and his friends walked to the clinic. Later, two friends carried the arm in to the clinic.
At the hospital, the emergency staff (nurses, LPNs, secretaries, transport team, and physicians) will all become involved (Table 54.2). Diagnostic personnel including x-ray and laboratory individuals will perform necessary testing. The surgical team then provides the necessary anesthesia; nurses; orthopedists; general, vascular, neural, or hand surgeons as well as circulators; and other OR staff. Then the patient is transferred to the recovery, regular ward, or intensive care staff for 24 h care depending on the patient’s condition and level of amputation (Table 54.3). After stability, the regular floor or ward staff and inpatient physical or occupational therapy programs will be initiated. The long-term posthospital rehabilitation program and staff will then follow, as well as the posthospital medical staff, to monitor for complications and possible need for repeat interventions.
Table 54.2
Personnel involved in patient care
Site of injury |
Friends |
Crowd |
Paramedics |
Hospital |
Emergency room staff
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