Basic Considerations

Does Endovenous Laser Ablation Induce Endothelial Damage at the Saphenofemoral Junction?

Heere-Ress E, Veensalu M, Wacheck V, et al (Erasmus Univ Med Ctr, Rotterdam, The Netherlands; Med Univ of Vienna, Austria) Dermatol Surg 37:1456–1463, 2011^§

Abstract

Background and Objective

One of the possible complications of endovenous laser ablation (EVLA) is thrombus progression into the common femoral vein or popliteal vein with the potential risk of pulmonary embolism or stroke. We set out to investigate the effect of laser energy applied under standardized treatment conditions on biomarkers of platelet and endothelial activation and on the hemostatic system.

Methods

Twenty patients with incompetence of the great saphenous vein were included in this prospective study. Blood samples of the iliofemoral and anticubital veins were collected before, during, and after EVLA. Plasma levels of soluble (s) P-selectin, soluble thrombomodulin (sTM), prothrombin fragment F1 + 2 (F1 + 2), and d-dimer were measured. (s) P-selectin and sTM were analyzed as surrogate markers of endothelial and platelet activation. F1 + 2 and d-dimer were monitored to quantify the degree of surgical trauma.

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