Effect of Statins in Venous Thrombosis Risk Reduction

Venous Thrombosis and Pulmonary Embolism


Dose-related Effect of Statins in Venous Thrombosis Risk Reduction


Khemasuwan D, Chae YK, Gupta S, et al (Albert Einstein Med Ctr, Philadelphia, PA; et al) Am J Med 124:852–859, 2011§



G.L. Moneta, MD



Evidence Ranking


• C



Expert Rating


• 2



Abstract



Background


Atherosclerosis and venous thromboembolism share similar pathophysiology based on common inflammatory mediators. The dose-related effect of statin therapy in venous thromboembolism remains controversial. This study investigated whether the use of antiplatelet therapy and statins decrease the occurrence of venous thromboembolism in patients with atherosclerosis.



Methods


We conducted a retrospective cohort study reviewing 1795 consecutive patients with atherosclerosis admitted to a teaching hospital between 2005 and 2010. Patients who had been treated with anticoagulation therapy were excluded. Patients who either used statins for <2 months or never used them were allocated to the nonuser group.



Results


The final analysis included 1100 patients. The overall incidence of venous thromboembolism was 9.7%. Among statin users, 6.3% (54/861) developed venous thromboembolism, compared with 22.2% (53/239) in the nonuser group (hazard ratio [HR] 0.24; P <.001). After controlling for confounding factors, statin use was still associated with a lower risk of developing venous thromboembolism (HR 0.29; P <.001). High-dose statin use (average 50.9 mg/day) (HR 0.25; P <.001) lowered the risk of venous thromboembolism compared with standard-dose statins (average 22.2 mg/day) (HR 0.38; P <.001). Dual antiplatelet therapy with aspirin and clopidogrel decreased occurrence of venous thromboembolism (HR 0.19; P <.001). Interestingly, combined statins and antiplatelet therapy further reduced the occurrence of venous thromboembolism (HR 0.16; P <.001).

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Apr 1, 2017 | Posted by in CARDIOLOGY | Comments Off on Effect of Statins in Venous Thrombosis Risk Reduction

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