Modified from Douglas PS, Khandheria B, Stainback RF, et al: ACCF/ASE/ACEP/ASNC/SCAI/SCCT/SCMR 2007 appropriateness criteria for transthoracic and transesophageal echocardiography. J Am Coll Cardiol 50:187-204, 2007.

2. What is the difference between echocardiography and Doppler?

Echocardiography usually refers to two-dimensional (2-D) ultrasound interrogation of the heart in which the brightness mode is used to image cardiac structures based on their density and location relative to the chest wall. Two-dimensional echocardiography is particularly useful for identifying cardiac anatomy and morphology, such as identifying a pericardial effusion, left ventricular aneurysm, or cardiac mass.

Doppler refers to interrogation of the movement of blood in and around the heart, based on the shift in frequency (Doppler shift) that ultrasound undergoes when it comes in contact with a moving object (usually red blood cells). Doppler has three modes:

Pulsed Doppler (Fig. 5-1, A), which can localize the site of flow acceleration but is prone to aliasing

Figure 5-1 Doppler assessment used in patients with aortic stenosis. A shows pulsed Doppler in the left ventricular outflow tract in a patient with aortic stenosis. The peak velocity of the spectral tracing (arrow) is 1.2 msec, indicating normal flow velocity proximal to the aortic valve. B shows continuous Doppler across the aortic valve revealing a peak velocity of 4.5 msec (dashed arrow). Therefore, the blood-flow velocity nearly quadrupled across the stenotic aortic valve, consistent with severe aortic stenosis.

Continuous-wave Doppler (Fig. 5-1, B), which cannot localize the level of flow acceleration but can identify very high velocities without aliasing

Color Doppler (Fig. 5-2), which uses different colors (usually red and blue) to identify flow toward and away from the transducer, respectively, and identify flow acceleration qualitatively by showing a mix of color to represent high velocity or aliased flow

Figure 5-2 Mitral regurgitation. Apical four-chamber view with color Doppler revealing severe mitral regurgitation (white arrows). Black arrows point to the mitral valve. Note that in actuality, the regurgitant jet is displayed in color, corresponding to the flow of blood. LA, Left atrium; LV, left ventricle; RA, right atrium; RV, right ventricle.

Doppler is particularly useful for assessing the hemodynamic significance of cardiac structural disease, such as the severity of aortic stenosis (see Fig. 5-1), degree of mitral regurgitation (see Fig. 5-2), flow velocity across a ventricular septal defect, or severity of pulmonary hypertension. The great majority of echocardiograms are ordered as echocardiography with Doppler to answer cardiac morphologic and hemodynamic questions in one study (e.g., a mitral stenosis murmur); 2-D echo to identify the restricted, thickened, and calcified mitral valve (Fig. 5-3); and Doppler to analyze its severity based on transvalvular flow velocities and gradients.