Drug retention in the coronary and femoral arteries is dependent on the route of administration in swine: assessment of intimal and adventitial endovascular and systemic pharmacokinetics and toxicology with nanoparticle albumin-bound paclitaxel




Objective


We have previously reported coronary efficiency data comparing multiple modes of coronary delivery, with results indicating nanoparticle retention of less than 0.5% with luminal and intimal delivery vs. more than 55% with adventitial delivery. This work has been expanded to test the relative efficiency of delivering common antirestenotic compounds to the artery wall and to examine pharmacokinetic and toxicity profiles of paclitaxel following coronary and femoral delivery.




Methods


Delivery of a nanoparticle albumin-bound paclitaxel (NAB-PTX, Abraxis Biosciences) was compared in swine across two different intravascular arterial delivery methods and systemic intravenous delivery. Low-dose vs. high-dose NAB-PTX was delivered to coronary (10 vs. 100 μg, respectively) and femoral vessels (50 vs. 500 μg, respectively) using adventitial [Mercator MedSystems Micro-Infusion Catheter (MIC)] and intimal [Acrotek Genie Drug Infusion Balloon (DIB)] delivery catheters. Local delivery was compared to a systemic intravenous dose of 50 mg. Longitudinal vascular distribution and tissue concentration were determined by LC/MS at 1 h and 3 days, and histology/toxicity was evaluated 3 days post-delivery.

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Nov 16, 2017 | Posted by in CARDIOLOGY | Comments Off on Drug retention in the coronary and femoral arteries is dependent on the route of administration in swine: assessment of intimal and adventitial endovascular and systemic pharmacokinetics and toxicology with nanoparticle albumin-bound paclitaxel

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