Deep Venous Thrombosis

Deep Venous Thrombosis

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Deep venous thrombosis (DVT) is a thrombosis within the deep venous system.


It most commonly affects the lower limb but may also include the iliac veins, IVC, SVC and upper limb veins.


Incidence


This is variable depending on the population but is estimated to occur in 10–30% of hospital patients and as high as 80% in critical illness and major trauma. They are more common in the left leg (longer pelvic course running behind both the right and left common iliac arteries).


Risk Factors, Complications and Management of DVT


Risk Factors



  • Major surgery (esp. lower limb and pelvic surgery)
  • Major trauma
  • Immobility
  • Dehydration
  • Prothrombotic medications (e.g. OCP)
  • Hyperosmolarity (e.g. HONC, nephrotic syndrome)
  • Coagulopathies (congenital and acquired)
  • Malignancy
  • Venous obstruction (e.g. external obstruction from a pelvic tumour, gravid uterus, May-Thurner syndrome)
  • Pregnancy (gravid uterus and prothombotic state)

Complications



  • Pulmonary embolism (PE)+/− sudden death
  • Recurrent thrombosis
  • Post-thrombotic syndrome. (Venous valvular incompetence with chronic reflux, venous hypertension and ulceration)
  • Pulmonary hypertension
  • Venous ischaemia (rare)
  • Budd-Chiari syndrome (hepatic venous outflow obstruction)

Management


Prophylaxis



  • General management

    • Treat underlying cause mobilise, hydrate

  • Mechanical prophylaxis

    • SCDs (sequential compression devices)
    • Compression hosiery

  • Chemical prophylaxis (prophylactic dose)

    • Heparin (unfractionated)
    • LMWH (fractionated heparin)

Treatment



  • Anti-coagulation (therapeutic dose)
  • Catheter-directed thrombolysis
  • Percutaneous mechanical thrombectomy
  • Open surgical thrombectomy

Lower Limb DVT


The majority develop in the BK segment including soleal sinuses, tibial veins and BK-popliteal vein. Fragmentation and embolisation is less common compared with an AK-DVT (AK-popliteal, SFV, CFV and iliac veins). An AK-DVT has a much higher incidence of PE and sudden death, but without treatment BK DVTs may propagate proximally.


Symptoms and Signs

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Jul 1, 2016 | Posted by in CARDIOLOGY | Comments Off on Deep Venous Thrombosis

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