Coronary artery disease





Visualization of the coronary arteries and regional wall motion



Normal coronary arteries



Fig 1.1


In a magnified short-axis view of the aorta slightly cephalad to the valve plane, the right coronary artery (RCA) and left coronary artery (LCA) ostia are seen arising from the right and left coronary sinuses of Valsalva, respectively. The left main coronary artery is easily visualized in nearly all patients. The right coronary is visualized less often.



Fig 1.2


Transesophageal echocardiography (TEE) images in a different patient demonstrate the course of the left main coronary artery as it passes behind the main pulmonary artery and bifurcates into the posterior direct circumflex (Cx) and more anteriorly the direct left anterior descending (LAD) coronary artery. This view was obtained starting in a short-axis view of the aorta to visualize the left main coronary ostium and then rotating the image plane until the bifurcation was seen. On the right, color Doppler demonstrates the predominantly diastolic flow in the left main, circumflex, and left anterior descending (LAD) coronary arteries.



Fig 1.3


A pulsed Doppler sample volume is positioned in the left anterior descending coronary artery. The spectral tracing shows low-velocity diastolic flow, with small systolic component, typical for normal coronary blood flow.



Fig 1.4


In this patient with an idiopathic dilated cardiomyopathy undergoing heart transplantation, the left main coronary artery is absent, and both the circumflex and left anterior descending arteries arise from the left coronary sinus of Valsalva as seen on TEE (left) and in the explanted heart (right).



Fig 1.5


In this intraoperative photograph of the aortic valve from the aortic root side, the forceps tip is at the ostium of the right coronary artery (left). The right coronary ostium is anterior and slightly more cephalad than the left main coronary artery (right) . The photograph is taken from the head of the operating table, and is therefore rotated 180 degrees from what is seen in TEE imaging.



Fig 1.6


In a magnified short-axis TEE image, the ostium of the right coronary artery (RCA) is seen.



Fig 1.7


The RCA is often more easily visualized in a long-axis view of the aortic root, as shown in this example.



Fig 1.8


The left ventricular wall segments are shown for an anatomic specimen in the same orientation as a transgastric short-axis view of the ventricle. The ventricle is divided into six segments at the base and midventricular level, as shown. The posterior wall is also called the inferior–lateral wall, using the standard nomenclature for regional wall motion analysis.



Fig 1.9


This schematic diagram of a short-axis view of the left (LV) and right ventricle (RV) in the same orientation as the transgastric short-axis views (left-side frame) illustrates the correlation between coronary anatomy and regional myocardial function. In the middle frame, the 17-segment model of the LV is seen, and in the right-side frame, the coronary perfusion of these segments is shown. There is some variability in the region supplied by the left circumflex artery (LCX), even at the base and midventricular levels. The apical region of the ventricle may be supplied by either the left anterior descending (LAD) or the right coronary artery (RCA) so that identification of the culprit vessel becomes problematic when only an apical abnormality is present.

(Reproduced with permission from Oxorn D, Edelist G, Smith MS. An introduction to transoesophageal echocardiography: II clinical applications. Can J Anaesth 1996; 43:278-294 [left-side frame], and from Lang R, Badano L, Victor Mor-Avi V et al. Recommendations for cardiac chamber quantification by echocardiography in adults: An update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. J Am Soc Echocardiogr 2015; 28:1–39 [middle and right-side frames]).




Comments


As shown in these examples, the proximal coronary arteries can often be visualized on TEE. The left main coronary artery arises from the left coronary sinus of Valsalva, is easily visualized in over 85% of patients and has a normal diameter of 4.2 ± 0.7 mm, with a slightly smaller average diameter in women (3.5 mm) compared with men (4.3 mm). The left main coronary artery bifurcates into the left anterior descending coronary, with a normal proximal diameter of 3.5 ± 1.0 mm, which supplies the anterior wall and anterior septum, and the circumflex coronary artery, with a normal diameter of 3.0 ± 0.6 mm, which supplies the lateral left ventricular wall. The right coronary artery arises from the right coronary sinus, with an average diameter of 3.6 ± 0.8 mm. The right coronary artery gives rise to the posterior descending coronary artery, supplying the inferior and posterior walls, in about 80% of patients (e.g., a right-dominant coronary circulation). The right coronary artery is not always visualized on TEE, being seen in about 50% of cases in one series.


The apical segments of the ventricle are often supplied by the left anterior descending artery, although the posterior descending coronary artery may extend to the inferior apex in some cases. The posterior (or inferior–lateral) left ventricular wall is variably supplied by either the circumflex or the posterior descending coronary artery. Coronary blood flow can be recorded using pulsed Doppler in many patients, with the typical pattern showing prominent diastolic flow, with a velocity about 0.6 cm/s, with little flow in systole. Although an increased velocity (>1 m/s) suggests stenosis and Doppler evaluation of coronary flow reserve is possible, these data are rarely used clinically.


TEE evaluation of the coronary arteries is most useful for detection of coronary artery aneurysms, coronary fistula, and anomalous origins from a different sinus of Valsalva or from the pulmonary artery. Although some studies have shown that TEE evaluation is sensitive and specific for detection of significant left main or proximal coronary stenosis, TEE has not gained clinical acceptance as an approach to evaluation of atherosclerotic coronary disease. In addition to variable image quality, the inability to visualize distal vessel anatomy is a major limitation. Echocardiographic evaluation of coronary disease currently relies on evaluation of regional myocardial function at rest and with stress.


Suggested reading




  • 1.

    Lenter C, editor: Geigy Scientific Tables, Vol. 5: Heart and Circulation, Basel, Switzerland, 1990, CIBA-GEIGY Limited, pp 173–181.


  • 2.

    Oxorn D, Edelist G, Smith MS: An introduction to transoesophageal echocardiography: II Clinical applications, Can J Anaesth 43:278–294, 1996.


  • 3.

    Lang R, Badano L, Victor Mor-Avi V, et al: Recommendations for cardiac chamber quantification by echocardiography in adults: An update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging, J Am Soc Echocardiogr 28:1–39, 2015.




Right coronary artery dissection


This 71-year-old man had severe symptomatic calcific aortic stenosis. When undergoing diagnostic coronary angiography, he suffered a spiral dissection of the right coronary artery that was initially treated with multiple stents. Despite efforts to reperfuse the right coronary distribution, he suffered a ventricular fibrillation arrest. TEE at the outside hospital showed a proximal ascending aortic dissection. He was airlifted to our medical center and brought directly to the operating room.



Fig 1.10


The right coronary angiogram demonstrates extravasation of contrast near the vessel origin in the proximal aorta. The close-up view (right) shows the spiraling echolucency in the right coronary consistent with a dissection.



Fig 1.11


After completion of the angioplasty, the right coronary artery appears widely patent, with the distal end of the guidewire seen in the posterior descending coronary branch.



Fig 1.12


On intraoperative TEE, the long-axis view of the ascending aorta demonstrates a luminal flap, originating near the right coronary ostium. The echo density in the false lumen suggests thrombus formation. Note that the aortic valve is heavily calcified.



Fig 1.13


The transgastric short-axis view of the left ventricle shows severe hypokinesis of the inferior wall, consistent with ischemia in the distribution of the right coronary artery.



Fig 1.14


The patient underwent replacement of the aortic valve and ascending aorta with a composite valve and conduit. The left main coronary artery was reimplanted into the graft and a bypass graft was placed to the distal right coronary artery, with the proximal right coronary artery oversewn. A small segment of the resected aorta shows the dissection plane between the endothelium and media of the vessel. The patient had an uneventful hospital course and was discharged home on the sixth postoperative day.



Fig 1.15


Microscopic examination of the aortic specimen shows the dissection plane through the media, filled with blood.




Comments


Coronary artery dissection can occur spontaneously or as a complication of cardiac catheterization. Coronary dissection is a rare cause of acute myocardial infarction in younger patients. Although there are no specific clinical predictors of spontaneous coronary dissection, it is more common in women than in men and the risk is increased during pregnancy.


Coronary dissection owing to diagnostic cardiac catheterization is rare but can result in acute severe myocardial ischemia, as in this case. The overall incidence of myocardial infarction with diagnostic coronary angiography is 0.06%, with infarction more often due to vessel thrombosis or embolization rather than to coronary dissection. When coronary dissection complicates a diagnostic or therapeutic percutaneous coronary procedure, the dissection flap may propagate retrograde into the aorta, as in this case.


Suggested reading




  • 1.

    Saw J: Spontaneous coronary artery dissection, Can J Cardiol 29(9):1027–1033, 2013.


  • 2.

    Crea F, Battipaglia I, Andreotti F: Sex differences in mechanisms, presentation and management of ischaemic heart disease, Atherosclerosis 241(1):157–168, 2015.


  • 3.

    Alfonso F, Bastante T, Cuesta J, et al: Spontaneous coronary artery dissection: Novel insights on diagnosis and management, Cardiovasc Diagn Ther 5(2):133–140, 2015.


  • 4.

    Lou X, Mitter SS, Blair JE, et al: Intraoperative coronary artery dissection in fibromuscular dysplasia, Ann Thorac Surg 99(4): 1442–1444, 2015.




Right coronary artery air


After cardiac surgery (especially when cardiac chambers have been opened), and in preparation for separation from cardiopulmonary bypass, the cardiac chambers are imaged to determine the presence of intracardiac air. If substantial air is present, there is concern that air entering the coronary ostia might interrupt coronary blood flow, resulting in myocardial ischemia. The surgeon will therefore make attempts to “de-air” the heart by applying suction to the ascending aorta in order to evacuate air as it passes through the aortic valve, and before it enters the coronary ostia. In extreme cases, actual needle aspiration of the left ventricular cavity may be undertaken.



Fig 1.16


In the TEE four-chamber view at 0 degrees rotation, there are multiple bright mobile echodensities (termed echocardiographic contrast) in all four chambers of the heart, suggesting that microbubbles are present in the left- and right-sided circulations. A pocket of air (bright density at the LV apex) is frequently enmeshed in the left ventricular apex.



Fig 1.17


In both short- (left) and long-axis (center) views of the aortic valve, microbubbles are seen in the aortic root. Microbubbles tend to accumulate in the sinus of Valsalva adjacent to the right coronary cusp (RCC), with preferential flow into the right coronary artery; this occurs because when the patient is lying supine, the right coronary artery is the most superior (right).



Fig 1.18


Transgastric views of the left ventricle in a short-axis (left) and two-chamber (right) view show that the inferior wall segments between the arrows are akinetic, but not thinned.




Comments


On echocardiography, air in the cardiac chambers appears as mobile echodensities, e.g., echo contrast. The echocardiographer may be asked to evaluate residual air as the patient is weaned from cardiopulmonary bypass. Air detected by TEE is associated with transient ST-segment elevation on the electrocardiogram (ECG) and wall motion abnormalities on two-dimensional (2D) imaging. The association between intracardiac air and neurologic events after cardiac surgery is less clear, with some studies suggesting that left-sided microbubbles are not predictive of neurologic recovery, but other studies showing better postoperative cognitive function in patients with fewer microbubbles after surgery.


Suggested reading




  • 1.

    Jha AK, Malik V, Hote M: Minimally invasive cardiac surgery and transesophageal echocardiography, Ann Card Anaesth 17(2):125–132, 2014.


  • 2.

    Akiyama K, Arisawa S, Ide M, et al: Intraoperative cardiac assessment with transesophageal echocardiography for decision-making in cardiac anesthesia, Gen Thorac Cardiovasc Surg 61(6):320–329, 2013.





Myocardial infarction



Anterior myocardial infarction


This 56-year-old man with no previous cardiac history presented with a 3-hour history of intermittent chest pain and anterior ST-segment elevation on ECG. He was taken directly to the cardiac catheterization laboratory where he was found to have an occluded proximal right coronary artery, with filling of the distal vessel by left-to-right collaterals, and an acute occlusion of the left anterior descending coronary artery. The left anterior descending occlusion could not be crossed. An intraaortic balloon pump was placed and he was referred for emergency coronary bypass grafting surgery. Preoperative echocardiography demonstrated a left ventricular ejection fraction of 29% with severe hypokinesis of the inferior wall and akinesis of the mid and apical segments of the anterior wall.



Fig 1.19


The ECG demonstrates Q-waves and ST elevation in leads VI–V3 consistent with an acute anteroseptal myocardial infarction. There also are small Q-waves in III and AVR without associated ST changes.



Fig 1.20


At coronary angiography there was an old occlusion of the right coronary artery. The left main and left circumflex showed only mild diffuse disease, but there was a complete proximal occlusion of the left anterior descending coronary (LAD) with contrast filling only a small diagonal branch to the basal anterior wall.



Fig 1.21


The left ventriculogram in a right anterior oblique view demonstrates normal endocardial motion at the ventricular base (arrows) with akinesis of the anterior wall, consistent with the acute event, and akinesis of the inferior wall, consistent in turn with the old myocardial infarction.



Fig 1.22


In the TEE four-chamber view at 0 degrees, the apical segments of the lateral wall and septum under the arrows are akinetic.



Fig 1.23


The image plane is rotated to 69 degrees to obtain a two-chamber view. The arrows indicate “hinge points” in the inferior and anterior walls; the myocardium below these points is akinetic.

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Dec 30, 2019 | Posted by in CARDIOLOGY | Comments Off on Coronary artery disease

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