contributions of the extracellular signal–regulated kinase and Akt pathways to neointimal hyperplasia

Basic Considerations


Adventitial contributions of the extracellular signal–regulated kinase and Akt pathways to neointimal hyperplasia


Havelka GE, Hogg ME, Martinez J, et al (Northwestern Univ, Chicago, IL) Am J Surg 202:515–519, 2011§



M.T. Watkins, MD



Evidence Ranking


• E



Expert Rating


• 3



Abstract



Background


We recently reported that the efficacy of nitric oxide (NO) appears to be based on both sex and hormone status. The mechanism responsible for this differential efficacy is unknown. The aim of this study was to characterize the effect of sex, hormones, and NO on the extracellular signal–regulated kinase (ERK) and Akt signaling pathways after arterial injury.



Methods


Male and female Sprague–Dawley rats underwent castration or sham surgery. Two weeks later, they underwent carotid artery balloon injury. Treatment groups included the following: control, injury, and injury + 1-[2-(carboxylato)pyrrolidin-1-yl]diazen-1-ium-1,2-diolate (PROLI/NO) (n = 5 per group). Arteries were harvested 2 weeks after injury and assessed for phospho-ERK (pERK) and phospho-Akt (pAkt) expression.

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Apr 1, 2017 | Posted by in CARDIOLOGY | Comments Off on contributions of the extracellular signal–regulated kinase and Akt pathways to neointimal hyperplasia

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