consumption and outcome in stable outpatients with peripheral artery disease

Epidemiology


Alcohol consumption and outcome in stable outpatients with peripheral artery disease


Garcia-Diaz AM, Marchena PJ, Toril J, et al (Primary Healthcare, Barcelona, Spain; Hosp Sant Boi, Barcelona, Spain; Centro Médico y de Rehabilitación, Castelldefels, Barcelona, Spain; et al) J Vasc Surg 54:1081–1087, 2011§



G.L. Moneta, MD



Evidence Ranking


• C



Expert Rating


• 1



Abstract



Background


The influence of alcohol consumption on outcome in patients with peripheral artery disease (PAD) has not been thoroughly studied.



Methods


Factores de Riesgo y ENfermedad Arterial (FRENA) is an ongoing, multicenter, observational registry of consecutive stable outpatients with arterial disease. We compared the mortality rate and the incidence of subsequent ischemic events in patients with PAD, according to their alcohol habits.



Results


As of August 2010, 1073 patients with PAD were recruited, of whom 863 (80%) had intermittent claudication (Fontaine stage II), 102 (9.5%) had rest pain (Fontaine stage III), and 108 (10%) had ischemic skin lesions (Fontaine stage IV). In all, 422 patients (39%) consumed alcohol during the study period. Over a mean follow-up of 13 months, 150 patients (14%) developed subsequent ischemic events (myocardial infarction 28, stroke 30, disabling claudication/critical limb ischemia 100), and 70 patients (6.5%) died. The incidence of subsequent events was the same in both subgroups: 11.8 events per 100 patient-years (rate ratio: 1.00; 95% confidence interval [CI], 0.72-1.41), but the mortality rate was significantly lower in alcohol consumers than in non-consumers: 2.78 vs 6.58 deaths per 100 patient-years (rate ratio: 0.42; 95% CI, 0.23-0.74; P = .002). This better outcome was consistently found in patients with Fontaine stages II and III or IV, and persisted after multivariate adjustment (relative risk: 0.49; 95% CI, 0.28-0.88).

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Apr 1, 2017 | Posted by in CARDIOLOGY | Comments Off on consumption and outcome in stable outpatients with peripheral artery disease

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