Congenital Heart Disease




INTRODUCTION


As invasive and noninvasive methods of assessment of ventricular performance evolve, the clinical importance of diastolic function in both children and adults with congenital heart disease has become better appreciated. Alterations in ventricular geometry and loading conditions are the hallmark of congenital heart disease and further complicate the quantitative evaluation of diastolic function. Additional intrinsic and extrinsic factors also may affect diastolic performance, significantly altering this phase of the cardiac cycle. Systolic ventricular function, atrial and ventricular compliance, ventricular filling pressure, pericardial constraint, and ventricular interaction may each have a significant effect on overall diastolic performance. This chapter will discuss current concepts in diastolic function in children and adults with congenital heart disease and detail ongoing clinical efforts regarding the assessment of diastolic performance in this population.




PATHOPHYSIOLOGY OF DIASTOLIC DYSFUNCTION IN CHILDREN


Diastole is a complex process involving both active and passive components. Abnormalities of relaxation and early rapid filling are often manifested by changes in the rate of relaxation and the amount of early rapid filling. Diastolic dysfunction also is manifested by changes in chamber stiffness or compliance. Adverse changes within the myocardial cytoskeleton are common in diastolic disease processes, with increases in collagen content and altered extracellular matrix composition leading to altered chamber compliance.


The rate of pressure decline within the ventricular chamber can be determined by invasive methods. Tau (τ), or pressure half-time, is the period of time for pressure to fall by 50% of its initial measured value. Impaired relaxation leads to a decreased rate of ventricular pressure decline. Lengthening of isovolumic relaxation time (IVRT) (defined as the time interval between aortic valve closure and mitral valve opening) is also characteristic of abnormal diastolic filling and can be evaluated noninvasively by M-mode or pulsed-wave Doppler echocardiography. However, neither IVRT nor τ elucidates whether dysfunction occurs in active or passive relaxation, which act in concert to cause a fall in ventricular pressure and augment filling. As diastolic disease progresses, increased ventricular end diastolic pressure further increases τ and pressure halt time, while concomitant changes in atrial compliance and filling pressure act to shorten IVRT duration.


Echocardiography, and in particular Doppler echocardiography, historically has been an essential noninvasive tool in the quantitative assessment of left ventricular (LV) diastolic function. Abnormalities of ventricular compliance and relaxation can be demonstrated by characteristic changes in mitral inflow and pulmonary venous Doppler patterns. The addition of newer methodologies including tissue Doppler echocardiography and flow propagation velocities enhanced the ability of echocardiographers to define and quantitate these adverse changes in diastolic performance. Because diastolic dysfunction often precedes systolic dysfunction, careful assessment of diastolic function is essential in the noninvasive characterization and evaluation of patients with congenital heart disease.


Normal Diastolic Function in Children


Normal maturation of the neonatal myocardium occurs over the first year of life, resulting in improved ventricular compliance with aging. Noninvasive evaluation of normal diastolic function in infants and children is influenced by several factors, including age, heart rate, and the respiratory cycle. Researchers have established reference values detailing both mitral and pulmonary venous Doppler velocities in a large cohort of children with unimpaired hearts ( Tables 25-1 , 25-2 , and 25-3 ). Similar to many echocardiographic parameters, these Doppler velocities also are significantly affected by loading conditions, making determination of diastolic dysfunction using these parameters alone very challenging in patients with congenital heart disease.



TABLE 25-1

NORMAL DOPPLER DATA ( N = 233): MITRAL VALVE FLOW VARIABLES AND LEFT VENTRICULAR ISOVOLUMIC RELAXATION TIME (STRATIFIED BY AGE GROUP)









































































































3-8 yrs (N = 75) 9-12 yrs (N = 72) 13-17 yrs (N = 76)
FAC TOR Mean 1 SD Mean 1 SD Mean 1 SD
E velocity (cm/sec) 92 14 86 15 88 14
E TVI (cm) 12.0 2.6 12.3 2.9 14.0 2.9
A velocity (cm/sec) 42 11 41 9 39 8
A TVI (cm) 3.7 1.1 3.7 1.0 3.7 1.1
A duration (msec) 136 22 142 21 141 22
E at A velocity (cm/sec) 16 7 14 5 12 4
E to A velocity ratio 2.4 0.7 2.2 0.6 2.3 0.6
E to A TVI ratio 3.7 2.0 3.7 1.5 4.2 1.7
Deceleration time (msec) 145 18 157 19 172 22
End mitral A to R wave interval (msec) 34 16 29 15 27 19
LV IVRT (msec) 62 10 67 10 74 13

A, atrial filling wave; E, early filling wave; IVRT, isovolumic relaxation time; LV, left ventricular; SD, standard deviation; TVI, time velocity integral.

From O’Leary PW et al: Diastolic ventricular function in children: A Doppler echocardiographic study establishing normal values and predictors of increased ventricular end diastolic pressure. Mayo Clin Proc 1998;73:616–628.


TABLE 25-2

NORMAL DOPPLER DATA ( N = 223): PULMONARY VEIN FLOW VARIABLES

























































































3-8 yrs (N = 75) 9-12 yrs (N = 72) 13-17 yrs (N = 76)
FAC TOR Mean 1 SD Mean 1 SD Mean 1 SD
Systolic velocity (cm/sec) 46 9 45 9 41 10
Systolic TVI (cm) 11.1 2.3 11.5 2.2 10.8 2.8
Diastolic velocity (cm/sec) 59 8 54 9 59 11
Diastolic TVI (cm) 8.8 1.8 9.2 2.5 12.1 3.1
Ratio of systolic to diastolic velocity 0.8 0.2 0.8 0.2 0.7 0.2
Ratio of systolic to diastolic TVI 1.3 0.3 1.3 0.4 0.9 0.3
Atrial reversal velocity (cm/sec) 21 4 21 5 21 7
Atrial reversal duration (msec) 130 20 125 20 140 28
Atrial reversal TVI (cm) 1.7 0.5 1.6 0.6 2.0 0.9

SD, standard deviation; TVI, time velocity integral.

From O’Leary PW et al: Diastolic ventricular function in children: A Doppler echocardiographic study establishing normal values and predictors of increased ventricular end diastolic pressure. Mayo Clin Proc 1998;73:616–628.


TABLE 25-3

INFLUENCES OF AGE AND HEART RATE ON DIASTOLIC DOPPLER VARIABLES IN CHILDREN


















































































































































UNIVARIATE ASSOCIATIONS BIVARIATE PARTIAL ASSOCIATIONS *
VARIABLE Age RR Age RR
Mitral E velocity
Mitral A velocity ↓↓ ↓↓
End A to R interval
Duration of A wave
Mitral deceleration time ↑↑↑ ↑↑↑
Mitral E wave TVI ↑↑ ↑↑↑ ↑↑↑
Mitral A wave TVI
Mitral E at A velocity ↓↓ ↓↓
Mitral E to A ratio (velocity) ↑↑↑ ↑↑↑
Mitral E to A ratio (TVI) ↑↑↑ ↑↑↑
LV IVRT ↑↑ ↑↑
PV systolic peak velocity
PV diastolic peak velocity
Peak PVAR velocity
PVAR duration ↑↑ ↑↑
PV systolic TVI
PV diastolic TVI ↑↑↑ ↑↑↑
PVAR TVI
PV systolic to diastolic ratio (velocity)
PV systolic to diastolic ratio (TVI) ↓↓
Ratio of PVAR to mitral A wave duration
Ratio of PVAR to mitral A wave TVI ↓↓ ↓↓

A, atrial; E, early; IVRT, isovolumic relaxation time; LV, left ventricular; PV, pulmonary vein; PVAR, pulmonary vein atrial reversal; RR RR interval; TVI, time velocity integral; — = no effect; ↑ = weak association ( R 2 < 0.10); ↑↑ = moderate association (0.10 < R 2 < 0.20); ↑↑↑ = strong association ( R 2 > 0.20).

From O’Leary PW et al: Diastolic ventricular function in children: A Doppler echocardiographic study establishing normal values and predictors of increased ventricular end diastolic pressure. Mayo Clin Proc 1998;73:616-628.

* Univariate associations column demonstrates the association between age or heart rate (RR interval) and each dependent variable without accounting for other influences. Bivariate partial associations column demonstrates the effect of age or heart rate on each dependent variable after controlling for the influence of the other independent variable (age or heart rate). Upward arrows indicate positive associations between age or RR interval and the measured variable; downward arrows indicate negative associations. The number of arrows shown increases as the degree of association increases.



Mitral Inflow Doppler


Mitral inflow Doppler represents the diastolic pressure gradient between the left atrium and the left ventricle ( Fig. 25-1 ) (see Chapter 10 ). The early diastolic filling wave, or E wave, is the dominant diastolic wave in children and young adults and represents the peak left atrial (LA)-to-LV pressure gradient at the onset of diastole. The deceleration time (DT) of the mitral E wave reflects the period of time needed for equalization of LA and LV pressures. The late diastolic filling wave, or A wave, represents the peak pressure gradient between the left atrium and the left ventricle in late diastole at the onset of atrial contraction. Normal mitral inflow Doppler is characterized by a dominant E wave, a smaller A wave, and a ratio of E and A waves (E/A ratio) between 1 and 3. Normal durations of mitral DT and IVRT vary with age and have been reported in both pediatric and adult populations. , Mitral inflow Doppler velocities are affected not only by changes in LV diastolic function but also by a variety of additional hemodynamic factors, including age, altered loading conditions, heart rate, and changes in atrial and ventricular compliance. , Interpretation of characteristic patterns of mitral inflow must be carefully evaluated with particular attention paid to the potential impact of each of these hemodynamic factors on mitral inflow Doppler velocities.




Figure 25-1


Spectrum of diastolic flow patterns in diastolic dysfunction in children.

(From Olivier M et al: Serial Doppler assessment of diastolic function before and after the Fontan operation. J Am Soc Echocardiogr 2003;16:1136-1143.)


As in the adult population, the earliest stage of LV diastolic dysfunction demonstrated by mitral inflow Doppler in children is abnormal relaxation. This Doppler pattern is characteristic of normal aging in adults and represents a mild decrease in the rate of LV relaxation with continued normal LA pressure. It is characterized by a reduced E-wave velocity, increased A-wave velocity, decreased E/A ratio less than 1, and a prolonged mitral DT and IVRT.


As diastolic dysfunction progresses, further changes in ventricular relaxation and compliance occur, leading to an increase in LA pressure. Increased LA pressure normalizes the initial transmitral gradient between the left atrium and the left ventricle, producing a “pseudonormalized” mitral inflow Doppler pattern with increased E-wave velocity and E/A ratio and normalized mitral DT and IVRT intervals. This pseudonormal Doppler pattern may be difficult to distinguish from normal mitral inflow Doppler; however, maneuvers that decrease ventricular preload, like the Valsalva maneuver, as well as additional evaluation of pulmonary venous inflow Doppler can help unmask this advanced degree of LV diastolic dysfunction.


Further deterioration of LV diastolic function results in restrictive ventricular filling with an additional increase in LA pressure and a concomitant decrease in ventricular compliance. The Doppler pattern of restrictive LV filling is characterized by additional increases in E-wave velocity, reduction in A-wave velocity, an increased E/A ratio greater than 3, and significant shortening of both mitral DT and IVRT.


Pulmonary Venous Doppler


Pulmonary venous Doppler combined with mitral inflow Doppler provides a more comprehensive assessment of LA and LV filling pressures (see Fig. 25-1 ). Pulmonary venous inflow consists of three distinct Doppler waves: a systolic wave (S wave), a diastolic wave (D wave), and a reversal wave with atrial contraction (Ar wave). In adolescents and adults with normal hearts, the characteristic pattern of pulmonary venous inflow consists of a dominant S wave, a smaller D wave, and a small Ar wave of low velocity and brief duration. In neonates and younger children, a dominant D wave is often present with a similar brief low-velocity, or even absent, Ar wave.


With worsening LV diastolic dysfunction, LA pressure rises, leading to diminished systolic forward flow into the left atrium from the pulmonary veins with relatively increased diastolic forward flow, resulting in a diastolic dominance of pulmonary venous inflow. More importantly, both the velocity and the duration of the pulmonary venous Ar wave are increased. Pediatric and adult studies have demonstrated that an Ar-wave duration more than 30 msec longer than the corresponding mitral A-wave duration or a ratio of pulmonary venous Ar-wave duration to mitral A-wave duration greater than 1.2 is predictive of elevated LV filling pressure ( Fig. 25-2 ).




Figure 25-2


A, Diagram depicting mitral valve and pulmonary vein Doppler flow tracings. B, Detecting elevated end diastolic pressure >18 mmHg (EDP) with use of ratio of pulmonary vein atrial reversal (PVAR) to mitral valve (MV) atrial filling wave (A) duration. A , atrial filling wave; A-d , duration of atrial filling wave; D , pulmonary vein diastolic flow wave; DT , mitral deceleration time; dTVI , time velocity integral of pulmonary vein diastolic flow wave; E , early filling wave; ECG , electrocardiogram; PVAR , pulmonary vein atrial reversal wave; PVAR-d , duration of pulmonary vein atrial reversal flow; S , pulmonary vein systolic flow wave; sTVI , time velocity integral of pulmonary vein systolic flow wave.

(From O’Leary PW et al: Diastolic ventricular function in children: A Doppler echocardiographic study establishing normal values and predictors of increased ventricular end-diastolic pressure. Mayo Clin Proc 1998;73:616-628.)


Tissue Doppler Imaging


Tissue Doppler imaging is particularly well suited to the quantitative evaluation of LV diastolic function ( Fig. 25-3 ) (see Chapter 12 ). Both early (Ea) and late (Aa) annular diastolic velocities can be readily obtained by tissue Doppler echocardiography. Similar to systolic tissue Doppler velocities, differences in diastolic velocities exist (1) between the subendocardium and the subepicardium, (2) from cardiac base to apex, and (3) among various myocardial wall segments. Previous studies have reported an excellent correlation between early annular diastolic mitral velocity and simultaneous invasive measures of diastolic function at cardiac catheterization. Early annular diastolic velocities also appear to be less sensitive to changes in ventricular preload compared with corresponding early transmitral Doppler inflow velocities. Significant alterations in preload, however, have been shown to affect these diastolic tissue Doppler velocities. The effect of afterload on tissue Doppler velocities is less controversial, with many studies documenting significant changes in systolic and diastolic annular velocities with changes in ventricular afterload. Therefore, the clinical use of tissue Doppler velocities in patients with valvular stenosis or other etiologies of altered ventricular afterload need to be interpreted carefully in light of this limitation.




Figure 25-3


Longitudinal tissue Doppler imaging velocities obtained at lateral mitral annulus ( A ), interventricular septum ( B ), and lateral tricuspid annulus ( C ). Tissue Doppler velocities include systolic (S), early diastolic (E), and late diastolic (A) myocardial velocities. Isovolumic contraction time (IVCT) and isovolumic relaxation time (IVRT) are also demonstrated.

(From Eidem BW et al: Impact of chronic left ventricular preload and afterload on Doppler tissue imaging velocities: A study in congenital heart disease. J Am Soc Echocardiogr 2005;18:830-838.)


Tissue Doppler velocities are helpful in the discrimination between normal and pseudonormal transmitral Doppler filling patterns ( Fig. 25-4 ). In addition to changes incurred by loading conditions, alterations in LA pressure and LV end diastolic pressure also affect the early transmitral diastolic velocity. However, the corresponding tissue Doppler velocity is typically decreased in patients with pseudonormal filling, allowing differentiation of this abnormal filling pattern from one of normal transmitral Doppler inflow. Clinical reports have suggested a ratio of the early transmitral inflow Doppler signal to the lateral mitral annular early diastolic velocity (mitral E/Ea) as a noninvasive measure of LV filling pressure. Nagueh and colleagues demonstrated a significant correlation of mitral E/Ea with invasively measured mean pulmonary capillary wedge pressure, while subsequent studies have further validated this ratio and reported its applicability in a variety of hemo-dynamic settings ( Fig. 25-5 ). Additional novel indices of LV diastolic function using tissue Doppler echocardiography have recently been reported that may further expand the role of this modality in the clinical evaluation of LV filling pressures.




Figure 25-4


Representative transmitral Doppler and tissue Doppler velocities in normal and diastolic dysfunction. Note significantly decreased tissue Doppler velocities with pseudonormal pattern.

(From Nagueh SF et al: Doppler tissue imaging: a noninvasive technique for evaluation of left ventricular relaxation and estimation of filling pressures. J Am Coll Cardiol 1997;30:1527-1533.)



Figure 25-5


Relation of E/EA to pulmonary capillary wedge pressure.

(From Nagueh SF et al: Doppler tissue imaging: a noninvasive technique for evaluation of left ventricular relaxation and estimation of filling pressures. J Am Coll Cardiol 1997;30:1527-1533.)


Tissue Doppler also is of considerable clinical value in the differentiation of constrictive from restrictive LV filling (see Chapter 24 ). Evaluation of patients with constrictive pericarditis and restrictive cardiomyopathy with two-dimensional echocardiography and even invasive cardiac catheterization may fail to confidently differentiate between these two disease states. Because the myocardium in patients with constrictive pericarditis is commonly normal, the corresponding tissue Doppler velocities are also normal. However, patients with restrictive cardiomyopathy have significantly decreased early diastolic and systolic tissue Doppler velocities, allowing separation of these two distinct clinical entities.


Tissue Doppler Studies in Children with Healthy Hearts


To date, a number of studies have established baseline reference values of tissue Doppler velocities in children ( Tables 25-4 and 25-5 ). , Similar to previously published adult reports, pediatric tissue Doppler velocities vary with age, heart rate, wall location, and myocardial layer ( Fig. 25-6 ). In addition, pulsed-wave tissue Doppler velocities are highly correlated with parameters of cardiac growth, most notably LV end diastolic dimension and LV mass, with the most significant changes in these velocities occurring during the first year of life ( Fig. 25-7 ). In a recently published large study of infants and children, tissue Doppler velocities did not correlate significantly with other more commonly utilized measures of systolic and diastolic ventricular performance, including LV shortening fraction, LV and RV myocardial performance indices, and transmitral inflow Doppler. This lack of correlation is likely due in part to pulsed-wave tissue Doppler assessments of longitudinal ventricular function, while other, more traditional, two-dimensional and Doppler methods assess radial and global measures of ventricular performance.



TABLE 25-4

DEMOGRAPHICS AND ECHOCARDIOGRAPHIC DATA IN STUDY PATIENTS






































































































































































































DEMOGRAPHICS <1 yr 1-5 yrs 6-9 yrs 10-13 yrs 14-18 yrs TOTAL
N 63 68 55 58 81 325
Male 29 39 27 38 44 177
Age (y) 0.40 ± 0.30 3.05 ± 1.51 7.91 ± 1.12 11.99 ± 1.11 16.0 ± 1.40 7.8 ± 6.0
Weight (kg) 6.6 ± 2.7 15.1 ± 5.4 33.8 ± 14.9 47.2 ± 16.3 66.1 ± 15.5 33.3 ± 25.2
BSA (m 2 ) 0.34 ± 0.08 0.62 ± 0.14 1.07 ± 0.27 1.37 ± 0.29 1.73 ± 0.25 1.0 ± 0.6
HR (bpm) 124 ± 16 105 ± 17 80 ± 11 75 ± 12 69 ± 16 90 ± 26
Echocardiographic
LV EDD (cm) 2.3 ± 0.3 3.1 ± 0.4 3.9 ± 0.4 4.3 ± 0.4 4.7 ± 0.4 3.6 ± 1.0
LV ESD (cm) 1.4 ± 0.2 1.9 ± 0.3 2.4 ± 0.3 2.7 ± 0.3 3.0 ± 0.4 2.3 ± 0.6
LV PWT (cm) 0.4 ± 0.1 0.6 ± 0.1 0.7 ± 0.1 0.8 ± 0.1 0.9 ± 0.2 0.7 ± 0.2
LV SWT (cm) 0.5 ± 0.1 0.6 ± 0.1 0.8 ± 0.1 0.8 ± 0.2 1.0 ± 0.2 0.7 ± 0.2
LV mass (g/m 2 ) 18.9 ± 6.5 43.6 ± 16.4 82.3 ± 28.3 110.1 ± 32.9 158.4 ± 48.5 81.8 ± 58.9
Mitral E velocity 79.7 ± 18.8 95.2 ± 19.5 94.4 ± 14.8 94.5 ± 16.0 90.3 ± 17.8 90.8 ± 18.5
Mitral A velocity 65.3 ± 13.3 61.3 ± 12.1 49.4 ± 12.5 49.5 ± 13.8 45.5 ± 13.2 54.4 ± 15.0
Mitral E/A ratio 12.4 ± 0.30 1.60 ± 0.46 1.99 ± 0.51 2.02 ± 0.58 2.13 ± 0.65 1.79 ± 0.61
PV S-wave velocity 44.6 ± 10.3 48.0 ± 8.9 50.7 ± 11.3 49.0 ± 11.1 47.7 ± 7.3 48.7 ± 9.2
PV D-wave velocity 46.0 ± 9.5 54.5 ± 11.0 53.3 ± 11.4 58.4 ± 12.1 57.9 ± 15.0 54.6 ± 12.9
PV A-reversal velocity 16.4 ± 6.3 20.6 ± 4.3 20.2 ± 3.8 21.2 ± 4.9 20.0 ± 5.2 20.5 ± 5.1
Tricuspid E velocity 53.3 ± 12.3 61.6 ± 12.5 60.5 ± 13.9 59.6 ± 11.4 60.4 ± 10.9 59.2 ± 12.4
Tricuspid A velocity 53.2 ± 13.0 48.3 ± 12.3 42.4 ± 10.8 39.2 ± 11.3 34.5 ± 11.2 43.3 ± 13.5
Tricuspid E/A ratio 1.01 ± 0.38 1.27 ± 0.31 1.49 ± 0.40 1.61 ± 0.47 1.88 ± 0.56 1.47 ± 0.53
SF (%) 38.9 ± 4.1 38.0 ± 3.6 37.4 ± 3.8 37.4 ± 4.2 36.4 ± 4.3 37.6 ± 4.1
LV MPI 0.33 ± 0.08 0.34 ± 0.07 0.32 ± 0.06 0.34 ± 0.06 0.34 ± 0.08 0.33 ± 0.08
RV MPI 0.29 ± 0.09 0.28 ± 0.07 0.29 ± 0.08 0.28 ± 0.08 0.29 ± 0.08 0.28 ± 0.08

From Eidem BW et al: Impact of cardiac growth on Doppler tissue imaging velocities: A study in healthy children. J Am Soc Echocardiogr 2004;17:212–221.


TABLE 25-5

PULSED-WAVE DOPPLER TISSUE VELOCITIES AND TIME INTERVALS IN HEALTHY CHILDREN BY AGE GROUP





















































































































































































AGE GROUP N E * -WAVE VELOCITY A * -WAVE VELOCITY S * -WAVE VELOCITY ICT IRT E/E * RATIO
Mitral annular
<1 yr 63 9.7 ± 3.3 (8.8-10.5) 5.7 ± 1.8 (5.3-6.2) 5.7 ± 1.6 (5.3-6.1) 77.4 ± 18.4 (72.7-82.0) 57.0 ± 14.8 (53.1-60.8) 8.8 ± 2.7 (8.1-9.5)
1 5 yrs 68 15.1 ± 3.4 (14.3-15.4) 6.5 ± 1.9 (6.1-7.0) 7.7 ± 2.1 (7.2-8.2) 76.9 ± 15.9 (72.8-80.9) 62.1 ± 13.2 (58.9-65.4) 6.5 ± 2.0 (6.0-7.0)
6-9 yrs 55 17.2 ± 3.7 (16.2-18.3) 6.7 ± 1.9 (6.2-7.3) 9.5 ± 2.1 (8.9-10.1) 77.9 ± 18.9 (72.4-83.4) 62.9 ± 11.9 (59.5-66.3) 5.8 ± 1.9 (5.3-6.4)
10—13 yrs 58 19.6 ± 3.4 (18.7-20.5) 6.4 ± 1.8 (5.9-6.9) 10.8 ± 2.9 * (10.0-11.5) 76.6 ± 16.2 (72.4-80.9) 62.6 ± 12.4 (59.4-65.9) 4.9 ± 1.3 (4.6-5.2)
14-18 yrs 81 20.6 ± 3.8 (19.7-21.4) 6.7 ± 1.6 (6.3-7.1) 12.3 ± 2.9 (11.6-12.9) 78.9 ± 15.4 (75.4-82.3) 69.5 ± 15.5 * (66.1-73.0) 4.7 ± 1.3 (4.4-5.0)
Total 325 16.5 ± 5.3 (16.0-17.1) 6.4 ± 1.9 (6.2-6.6) 9.3 ± 3.4 (8.9-9.7) 77.5 ± 16.7 (75.7-79.5) 63.2 ± 14.4 (61.7-64.9) 6.1 ± 2.4 (5.9-6.4)
Septal
<1 yr 63 8.1 ± 2.5 (7.5-8.7) 6.1 ± 1.5 (5.7-6.4) 5.4 ± 1.2 (5.1-5.7) 77.5 ± 17.5 (73.0-82.0) 53.0 ± 11.7 (50.0-56.0) 10.3 ± 2.7 (9.7-11.0)
1 5 yrs 68 11.8 ± 2.0 (11.3-12.3) 6.0 ± 1.3 (5.7-6.4) 7.1 ± 1.5 (6.8-7.5) 80.1 ± 15.5 (76.3-83.9) 59.8 ± 12.0 (56.9-62.7) 8.1 ± 1.8 (7.7-8.5)
6-9 yrs 55 13.4 ± 1.9 (12.8-13.9) 5.9 ± 1.3 (5.5-6.3) 8.0 ± 1.3 (7.6-8.4) 82.8 ± 15.3 (78.4-87.2) 65.6 ± 10.7 (62.5-68.7) 7.2 ± 1.6 (6.8-7.7)
10—13 yrs 58 14.5 ± 2.6 (13.8-15.2) 6.1 ± 2.3 (5.6-6.7) 8.2 ± 1.3 (7.9-8.5) 87.9 ± 16.4 * (83.6-92.2) 72.5 ± 12.3 (69.3-75.8) 6.6 ± 1.4 (6.3-7.0)
14-18 yrs 81 14.9 ± 2.4 (14.3-15.4) 6.2 ± 1.5 (5.9-6.6) 9.0 ± 1.5 (8.7-9.3) 88.4 ± 15.6 (84.9-91.9) 77.5 ± 14.5 (74.3-80.8) 6.4 ± 1.5 (6.1-6.8)
Total 325 12.6 ± 3.4 (12.2-13.0) 6.1 ± 1.6 (5.9-6.3) 7.6 ± 1.9 (7.4-7.8) 83.5 ± 16.5 (81.7-85.4) 66.1 ± 15.3 (64.4-67.9) 7.7 ± 2.3 (7.5-8.0)
Tricuspid annular
<1 yr 63 13.8 ± 8.2 (11.7-15.9) 9.8 ± 2.4 (9.1-10.5) 10.2 ± 5.5 (8.8-11.7) 68.7 ± 18.2 (63.9-73.5) 52.0 ± 12.9 (48.5-55.4) 4.4 ± 2.3 (3.8-5.0)
1 5 yrs 68 17.1 ± 4.0 (16.1-18.1) 10.9 ± 2.7 (10.2-11.6) 13.2 ± 2.0 (12.7-13.7) 77.7 ± 15.0 (73.9-81.5) 59.0 ± 13.9 (55.4-62.5) 3.8 ± 1.1 (3.5-4.1)
6-9 yrs 55 16.5 ± 3.0 (15.7-17.4) 9.8 ± 2.7 (9.0-10.6) 13.4 ± 2.0 (12.8-14.0) 91.8 ± 21.5 (85.5-98.0) 58.5 ± 17.5 (53.4-63.6) 3.6 ± 0.8 (3.4-3.9)
10—13 yrs 58 16.5 ± 3.1 (15.7-17.4) 10.3 ± 3.4 (9.3-11.2) 13.9 ± 2.4 (13.2-14.5) 98.1 ± 21.7 (92.2-103.9) 61.7 ± 19.9 (56.4-67.1) 3.5 ± 1.4 (3.2-3.9)
14-18 yrs 81 16.7 ± 2.8 (16.0-17.3) 10.1 ± 2.6 (9.5-10.7) 14.2 ± 2.3 (13.7-14.7) 101.9 ± 20.4 (97.2-106.6) 62.9 ± 18.9 (58.5-67.3) 3.7 ± 1.0 (3.5-3.9)
Total 325 16.1 ± 4.7 (15.6-16.7) 10.2 ± 2.8 (9.9-10.5) 13.0 ± 3.4 (12.6-13.4) 88.2 ± 23.1 (85.6-90.8) 59.0 ± 17.2 (57.0-60.9) 3.8 ± 1.4 (3.6-4.0)

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Mar 23, 2019 | Posted by in CARDIOLOGY | Comments Off on Congenital Heart Disease

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