Cerebrovascular Disease in the Elderly



Fig. 6.1
Hazard ratio for stroke and death favors carotid artery stenting in younger patients and carotid endarterectomy in older patients with high grade carotid stenosis




Key Points





  • Stroke is an important cause of death and leading cause of disability in the United States


  • Risk factors predisposing to stroke are more frequent among elderly


  • Stroke is more common among the elderly


  • Stroke outcome is worse in the elderly


  • Control of risk factors reduces stroke rates regardless of age


  • Patients age 75 and older with 50–99% stenosis benefit from carotid endarterectomy more than younger patients with the same degree of stenosis


  • Elderly patients with high-grade carotid artery stenosis of 70% or more also benefit from carotid endarterectomy


  • Carotid artery stenting in patients aged 70 years or more is associated with an increased risk of stroke and death compared to carotid endarterectomy


  • Asymptomatic high-grade carotid artery stenosis may be associated with cognitive impairment, and more information is needed to explore its impact on the functional status of older individuals



References



1.



2.

Warlow C, Sudlow C, Dennis M, Wardlaw J, Sandercock P. Stroke. Lancet. 2003;362:1211–24.CrossRefPubMed


3.

Centers for Disease Control and Prevention (CDC). Prevalence of stroke – United States, 2005. MMWR Morb Mortal Wkly Rep. 2007;56:469–74.


4.

Wolf PA, D’Agostino RB, Belanger AJ, Kannel WB. Probability of stroke: a risk profile from the Framingham Study. Stroke. 1991;22:312–8.CrossRefPubMed


5.

Kelly-Hayes M, et al. The influence of gender and age on disability following ischemic stroke: the Framingham Study. J Stroke Cerebrovasc Dis. 2003;12:119–26.CrossRefPubMed


6.

Kammersgaard LP, et al. Short- and long-term prognosis for very old stroke patients. The Copenhagen Stroke Study. Age Ageing. 2004;33:149–54.CrossRefPubMed


7.

El-Saed A, et al. Geographic variations in stroke incidence and mortality among older populations in four US communities. Stroke. 2006;37:1975–9.CrossRefPubMed


8.

Centers for Disease Control and Prevention (CDC). Disparities in deaths from stroke among persons aged <75 years – United States, 2002. MMWR Morb Mortal Wkly Rep. 2005;54:477–81.


9.

Rosamond W, et al. Heart disease and stroke statistics – 2007 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation. 2007;115:e69–171.CrossRefPubMed


10.

Brown DL, et al. Projected costs of ischemic stroke in the United States. Neurology. 2006;67:1390–5.CrossRefPubMed


11.

Seshadri S, et al. The lifetime risk of stroke: estimates from the Framingham Study. Stroke. 2006;37:345–50.CrossRefPubMed


12.

Heiss G, et al. Carotid atherosclerosis measured by B-mode ultrasound in populations: associations with cardiovascular risk factors in the ARIC study. Am J Epidemiol. 1991;134:250–6.CrossRefPubMed


13.

Patel A, et al. Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes. N Engl J Med. 2008;358:2560–72.CrossRefPubMed


14.

Laakso M. Benefits of strict glucose and blood pressure control in type 2 diabetes: lessons from the UK Prospective Diabetes Study. Circulation. 1999;99:461–2.CrossRefPubMed


15.

Gerstein HC, et al. Effects of intensive glucose lowering in type 2 diabetes. N Engl J Med. 2008;358:2545–59.CrossRefPubMed


16.

Wolf PA, D’Agostino RB, Kannel WB, Bonita R, Belanger AJ. Cigarette smoking as a risk factor for stroke. The Framingham Study. JAMA. 1988;259:1025–9.CrossRefPubMed


17.

Wolff T, Miller T, Ko S. Aspirin for the primary prevention of cardiovascular events: an update of the evidence for the U.S. Preventive Services Task Force. Ann Intern Med. 2009;150:405–10.CrossRefPubMed


18.

Wolf PA, et al. Preventing ischemic stroke in patients with prior stroke and transient ischemic attack: a statement for healthcare professionals from the Stroke Council of the American Heart Association. Stroke. 1999;30:1991–4.CrossRefPubMed


19.

Bucher HC, Griffith LE, Guyatt GH. Effect of HMGcoA reductase inhibitors on stroke. A meta-analysis of randomized, controlled trials. Ann Intern Med. 1998;128:89–95.CrossRefPubMed


20.

Avellone G, et al. Efficacy and safety of long-term ezetimibe/simvastatin treatment in patients with familial hypercholesterolemia. Int Angiol. 2010;29:514–24.PubMed


21.

Crouse JR, et al. Measuring Effects on intima media Thickness: an Evaluation Of Rosuvastatin in subclinical atherosclerosis – the rationale and methodology of the METEOR study. Cardiovasc Drugs Ther. 2004;18:231–8.CrossRefPubMed


22.

Taylor AJ, et al. ARBITER: Arterial Biology for the Investigation of the Treatment Effects of Reducing Cholesterol: a randomized trial comparing the effects of atorvastatin and pravastatin on carotid intima medial thickness. Circulation. 2002;106:2055–60.CrossRefPubMed

Only gold members can continue reading. Log In or Register to continue

Stay updated, free articles. Join our Telegram channel

Jul 18, 2017 | Posted by in CARDIOLOGY | Comments Off on Cerebrovascular Disease in the Elderly

Full access? Get Clinical Tree

Get Clinical Tree app for offline access