Introduction
Cardiac imaging has undergone significant advancements since the start of the 21st century. The last two decades have seen improvements in all imaging modalities used to visualize the heart, including echocardiography, cardiac computed tomography (CT), and cardiac magnetic resonance imaging (MRI). These advancements, including new equipment and techniques, offer better image quality, increased accuracy, and a wider range of capabilities. As a result, more sophisticated imaging options are now available for evaluating cardiac anatomy, ventricular function, and blood flow across valves, leading to a deeper understanding of coronary artery disease, heart failure, and structural heart diseases. The integration of artificial intelligence and machine learning in cardiac imaging has even led to the discovery of previously unnoticed disease patterns and a more personal approach to clinical care.
The evolution of cardiac imaging has also revolutionized the field of cardiac surgery by streamlining the preoperative planning phase and guiding complex procedures. Preoperatively, these imaging modalities are used to identify, quantify, and understand the underlying cardiac disease, informing surgical decisions. Intraoperative transesophageal echocardiography (TEE) provides real-time monitoring of underlying pathophysiology, guiding beating heart procedures, supporting surgical planning, and allowing for assessment of surgical results. Cardiac imaging is also crucial in the postoperative period to diagnose and manage complications. Lastly, noninvasive imaging is often employed to evaluate and monitor long-term surgical results.
Intraoperative TEE was first introduced in the 1980s, initially only for monitoring left ventricular (LV) function before and after coronary artery bypass grafting (CABG). Since then, echocardiography has become an essential tool for the preoperative and intraoperative management of patients undergoing a range of cardiac procedures. In the last two decades, three-dimensional (3D) echocardiography has emerged as a means of quantifying LV function and structural heart disease, offering more accurate and reproducible measurements of LV volumes and systolic function. In 2003, guidelines for the use of echocardiography, including TEE, were presented by the American College of Cardiology, American Society of Echocardiography (ASE), and American Heart Association, building on previous guidelines from the American Society of Anesthesiologists and Society of Cardiovascular Anesthesiologists (SCA). Echocardiography is now often the first choice for cardiac evaluation due to its high resolution, portability, affordability, and lack of radiation exposure.
Echocardiography
General principles
Echocardiographic images are constructed by transmitting high-frequency sound waves from a transducer composed of piezo-electric crystals. These waves reflect off cardiac structures, and the same transducer receives the returning signals. By knowing when the signal was sent, the speed of the sound in the tissue, and the time it takes for the reflected signal to return to the transducer, the position of the structure responsible for the reflection can be calculated. An image from these signals can thus be created. The quality of the image relies on many factors, including the media through which the sound is traveling, the orientation of the structures in relation to the ultrasound beam, and the composition of the structure. Sound travels incredibly well through water and blood, reasonably well through tissue, but poorly through air and bones. Therefore, echocardiographers use windows (between the ribs, sternum, and lungs) such as parasternal, apical, subcostal, suprasternal, transesophageal, or intracardiac to ensure good penetration of ultrasound. The fact that sound transmitted from a TEE transducer has less distance to travel (which means less signal lost to scatter) and mainly travels through muscle and blood (and rarely air) explains why the quality of TEE images is usually better than transthoracic echocardiography (TTE) imaging.
Echocardiographic displays include M-mode, two-dimensional (2D), and 3D imaging. The M-mode echocardiogram has superior temporal resolution and can be thought of as a display of the motion of a single cut through the heart over time ( Fig. 6.1 ). It is now used primarily to quantify the timing of intracardiac events.
M-mode view showing the left ventricular cavity (A) and the mitral valve (B) over the cardiac cycle (see ECG tracing) during systole and diastole. IVS , interventricular septum; LV , left ventricle; LVPW , left ventricle posterior wall.
Two-dimensional echocardiography ( Fig. 6.2 ) provides a display with better spatial resolution and excellent temporal resolution. Three-dimensional echocardiography provides the best display of the spatial relationships of various structures and flow patterns, and its resolution continues to improve.
Two-dimensional echocardiographic image. RV , right ventricle; LV , left ventricle; LA , left atrium; LVPW , left ventricle posterior wall.
Doppler echocardiography and color flow imaging, which provide reliable hemodynamic assessment, not only have replaced many invasive hemodynamic procedures but can also be superior to them under certain circumstances. Intracardiac blood flow velocities and myocardial motion are assessed by the Doppler principle, first described by the Austrian physicist Christian Doppler in 1842. The wavelength of sound reflecting off moving blood particles will be shorter if blood is moving toward the transducer and longer if moving away. This difference in frequency, known as the Doppler shift, can be used in the calculation of blood velocity ( Fig. 6.3 ).
Diagram of the Doppler effect; RBCs , red blood cells.
(From Oh JK, Seward JB, Tajik AJ, eds. The Echo Manual. Lippincott Williams & Wilkins; 2006.)
The angle of the ultrasound beam and the direction of blood flow are critically important in this calculation; thus, the beam should be aligned as parallel to the blood flow as possible. Several modalities of Doppler echocardiography can be used. Pulsed wave (PW) Doppler has excellent spatial resolution, permitting sampling of local blood flow velocities at a specific region (sample volume). This modality is particularly useful for assessing the relatively low-velocity flows associated with LV outflow tract, pulmonary venous flow, or left atrial appendage flow ( Fig. 6.4 ).
Pulsed wave (PW) Doppler has excellent spatial resolution, permitting sampling of local blood flow velocities at a specific region, for example the aortic valve (A) and left ventricular outflow tract (B).
Continuous wave Doppler records signal along the entire length of the ultrasound beam and permits measurement of very high velocities, such as in aortic stenosis ( Fig. 6.5 ).
Continuous wave (CW) Doppler of aortic stenosis (A) and tricuspid regurgitation (B). The continuous wave Doppler records signal along the entire length of the ultrasound beam and permits measurement of very high velocities.
Doppler color flow imaging is typically used in the assessment of regurgitant flows, and velocities and directions of the flow are displayed using a color scale ( Fig. 6.6 ).
Apical three-chamber view in color-Doppler form. The red region (A) shows upward flow toward the apex and the transducer. The blue region (B) shows flow into the left ventricular outflow tract, away from the transducer.
However, it must be remembered that the color display represents the velocity, and not the volume, of the regurgitant blood, as one would see on an angiogram.
Transthoracic echocardiography
Standard views.
TTE is a widely available, reproducible, noninvasive ultrasound imaging modality, often used as a first-line cardiac imaging modality. Comprehensive echocardiographic examination typically involves integrating imaging of the heart from multiple orientations to fully visualize cardiac structures. There are four standard transducer positions: the parasternal, apical, subcostal, and suprasternal windows ( Fig. 6.7 ).
Imaging planes of the heart (A) and standard transducer windows for TTE (B).
(From Mitchell C, Rahko PS, Blauwet LA, et al. Guide for performing a comprehensive transthoracic echocardiographic examination in adults: recommendations from the American Society of Echocardiography . J Am Soc Echocardiogr. 2019;32:1-64.)
Parasternal long-axis (PLAX) view.
The TTE examination usually begins with the patient in the left lateral decubitus position and by placing the transducer in the left parasternal region, usually in the third or fourth left intercostal space. From this position, images can be acquired along the long and short axes ( Fig. 6.8 ).
Anatomic section (A) with a corresponding still frame of 2D echocardiographic image (B) of the parasternal long-axis view. RV, right ventricle; IVS, interventricular septum; LV, left ventricle; PWT, posterior wall thickness; LVOT, left ventricular outflow tract; LA, left atrium; Ao, aorta
(A from Tajik AJ, Seward JB, Hagler DJ, et al. Two-dimensional real-time ultrasonic imaging of the heart and great vessels: technique, image orientation, structure identification, and validation. Mayo Clinic Proceedings. 1978;53:271-303.)
Parasternal short-axis (PSAX) view.
After acquiring the PLAX images, PSAX views of the heart are obtained by rotating the transducer clockwise ( Fig. 6.9 ).
Parasternal short-axis (PSAX) view and corresponding schematic demonstrating the right ventricular outflow tract (RVOT) and pulmonary artery (PA) with the right and left pulmonary arteries. AV , aortic valve; PV , pulmonary valve
Superior and inferior transducer manipulations permit the demonstration of cardiac structures at the base (aortic valve), basal LV (mitral valve), mid-LV (papillary muscle), and apical LV levels ( Figs. 6.10 , 6.11 , and 6.12 ).
Parasternal window short-axis (PSAX) view and corresponding schematic demonstrating aortic valve (AV), left atrium (LA), right atrium (RA), tricuspid valve (TV), right ventricular outflow tract (RVOT), pulmonary valve (PV), and interatrial septum (IAS).
Parasternal window short-axis (PSAX) at the level of the aortic valve and corresponding schematic; subtle adjustments of the transducer allow visualization of the origins of the right (RCA) and left (LCA) coronary arteries.
Parasternal short-axis (PSAX) views and corresponding schematics demonstrating the left ventricle at the mitral valve level (A and B). The mitral orifice has a characteristic “fish-mouth” appearance. A cross-section of the right ventricle is also seen. More inferior angulation results in the delineation of the left ventricle at the papillary muscle level (C and D) and the apical segments (E, F).
(Modified from Mitchell C, Rahko PS, Blauwet LA, et al. Guidelines for performing a comprehensive transthoracic echocardiographic examination in adults: recommendations from the American Society of Echocardiography. J Am Soc Echocardiogr. 2019;32:1-64.)
Parasternal views are used for the assessment of LV wall motion and coronary artery disease ( Fig. 6.13 ).
Relationship of myocardial segments to the typical distributions of the right coronary artery (RCA), the left anterior descending coronary artery (LAD), and the circumflex coronary artery (CX).
Apical views.
The next set of images is acquired from the apical window ( Figs. 6.14 , 6.15 , and 6.16 ).
In the apical four-chamber view, the left ventricle appears as an ellipse, with visualization of the interventricular septum (IVS), apex, and lateral walls. A corresponding view from a pathologic specimen is shown in the lower panel. RV , right ventricle; LV , left ventricle; RA , right atrium; LA , left atrium; TV , tricuspid valve; MV , mitral valve; IVS , interventricular septum; IAS , interatrial septum
(C Adapted from Tajik AJ, Seward JB, Hagler DJ, et al. Two-dimensional real-time ultrasonic imaging of the heart and great vessels: technique, image orientation, structure identification, and validation. Mayo Clinic Proceedings. 1978;53:271-303.)
The apical five-chamber view permits imaging of the left ventricular outflow tract (LVOT), right and left cusps of the aortic valve, and proximal ascending aorta (Asc Ao). LV , left ventricle; LA , left atrium; IVS , interventricular septum; RV , right ventricle; LA , left atrium.
The apical long-axis view and apical two-chamber views with corresponding schematics. The long axis of the three-chamber view (A,B) allows visualization of the left ventricle (LV), left ventricular outflow tract (LVOT), and aortic valve (AV). Further rotation of the transducer produces the two-chamber view (C,D); in this orientation, the anterior, inferior, and apical walls of the left ventricle are visualized, along with the left atrium (LA) and its appendage. In some patients, the left upper pulmonary vein is well seen in this view. MV , mitral valve.
Subcostal views.
The subcostal views are obtained by placing the transducer in the midline, with the patient supine. This position allows visualization of the liver parenchyma, hepatic vessels, and inferior vena cava (IVC), as well as of the right ventricle (RV), the inferior interventricular septum, and anterolateral LV walls ( Fig. 6.17 ).
Four chamber subcostal view (A, B) and subcostal view with the transducer angulated toward the liver and normal inferior vena cava (IVC) (C, D). RA , right atrium; RV , right ventricle; LV , left ventricle; TV , tricuspid valve; IVS , interventricular septum; MV , mitral valve; LA , left atrium; IAS , interatrial septum.
Based on the diameter and the collapsibility with respiration or sniff of the IVC ( Fig. 6.18 ), right atrial pressure (RAP) is estimated. The subcostal four-chamber view is also very useful for visualizing anterior pericardial effusions.
M-mode echocardiogram of IVC, and images are captured during inspiration and expiration.
Suprasternal notch.
For visualization of the distal ascending, transverse, and proximal descending aorta, as well as the left aortic arch, the transducer is positioned in the suprasternal notch. The take-off of the great vessels may also be appreciated ( Figs. 6.19 and 6.20 ).
(A and B) demonstrate views from the suprasternal notch window, which visualize the ascending aorta (Asc Ao), transverse arch and its branches, along with the descending aorta. The right pulmonary artery is seen in the cross-section behind the ascending aorta. Asc Ao , ascending aorta; Desc Ao , descending aorta; Brac A , brachiocephalic artery; LCCA , left common carotid artery; LSA , left subclavian artery; RPA , right pulmonary artery.
As seen in (A) and (B), imaging in the suprasternal notch short-axis plane allows evaluation of the left brachiocephalic vein and the superior vena cava, visualized anterior to the aorta in cross-section. Ao , aorta; SVC , superior vena cava; L Brac Vein , left brachiocephalic vein; RPA , right pulmonary artery.
Basic measurements.
As seen in Fig. 6.21 , standard 2D measurements of the left ventricle are made at end-diastole and end-systole. Additional measurements include left atrial dimension and aortic root diameters at three levels ( Fig. 6.22 ).
Standard 2D measurements at end-diastole (A) and end-systole (B); IVS thickness (arrow 1) , LV dimension (arrow 2) , posterior wall thickness (arrow 3) , RV diameter (arrow 4) . Measurements should be taken at the base of the left ventricle. The arrow in panel B indicates the LV end-systolic dimension.
In (A), the arrow indicates the left atrial dimension. In (B), aortic dimensions are measured at the level of the sinus of Valsalva (arrow 1) , the sinutubular junction (arrow 2) , and ascending aorta (arrow 3) .
Calculation of left ventricular ejection fraction.
The quantification of cardiac function is fundamental to cardiac imaging, with echocardiography being the most commonly used noninvasive modality. Left ventricular ejection fraction (LVEF) is the most commonly reported measure of global LV systolic function. However, it should be emphasized that echocardiography allows for the assessment of various components of global LV function, including global longitudinal strain (GLS), stroke volume, cardiac index, and regional wall motion analysis.
Several methods have been proposed for the quantitative assessment of LVEF. A qualitative visual assessment (“eyeballing”) of LVEF is reasonably reliable when performed by an experienced echocardiographer but has a considerable interobserver variation. The Teichholz method is often used in clinical practice for LVEF calculation. LV volume is calculated using only LV diameter (D) measured in the single dimension, as seen in Fig. 6.23 .
In (A), the arrow indicates the end-diastolic dimension (ED), and the arrow in (B) measures the end-systolic dimension (ES).
This method is simple, but its accuracy depends on geometric assumptions about LV shape; therefore, it is not useful in cases of wall motion abnormalities or cardiomyopathy. Therefore, whenever possible, the LVEF should be measured more objectively by using volumetric measurements. The biplane method of discs (modified Simpson method) using area tracings of the LV cavity is the currently recommended 2D method for the measurement of LVEF ( Fig. 6.24 ).
The left ventricular volumes should be traced at the border between the compacted and noncompacted myocardium (A, C) so that the trabeculated myocardium is included in the left ventricular volumes.
(From Oh JK, Seward JB, Tajik AJ, eds. The Echo Manual. Lippincott Williams & Wilkins, 2006.)
Ejection fraction (EF) is calculated from end-diastolic volume (EDV) and end-systolic volume (ESV) estimates using the following formula: EF = (EDV − ESV)/EDV .
Assessment of right atrial pressure and right ventricular systolic pressure.
RAP is estimated by measuring the diameter and degree of collapsibility of the IVC imaged from the subcostal view during inspiration ( Table 6.1 , Fig. 6.25 ).
TABLE 6.1
Right Atrial Pressures Estimated by IVC Diameter and Collapse
| RAP | IVC diameter | Collapse during sniff | |
|---|---|---|---|
| Normal | 3 mmHg | ≤2.1 cm | >50% |
| Intermediate | 8 mmHg | All the rest | |
| Elevated | 15 mmHg | >2.1 cm | <50% |
Subcostal view showing IVC diameter (A) and a collapse in size with inspiration (B).
The gradient estimated by the peak tricuspid regurgitation velocity (TRV) measured by continuous wave Doppler ( Fig. 6.25 B) reflects the pressure difference during systole between the RV and the right atrium (RA). Using the simplified Bernoulli equation (ΔP = 4V2) and the RAP, one can calculate the right ventricular systolic pressure (RVSP) with the following equation : RVSP = 4 (peak TRV 2 ) + RAP . In the absence of right ventricular outflow obstruction, the RVSP is equivalent to pulmonary artery systolic pressure (PASP).
Intraoperative transesophageal echocardiography
The use of intraoperative TEE began in 1971, with the measurement of flow in the aortic arch, followed by the use of M-mode and 2D imaging. Since then, TEE has become the main imaging modality in the operating room and a critical component in surgical planning and timely assessment of surgical intervention. It also enables the determination of LV systolic function early after cardiopulmonary bypass (CPB) and provides an opportunity to correct suboptimal surgical results before leaving the operating room. For example, intraoperative TEE has particular prognostic importance in patients undergoing mitral valve (MV) repair and can help identify the need for additional pump runs as a result of findings.
TEE provides superior quality in imaging of the heart and great vessels owing to excellent ultrasound penetration from the esophagus. The probe location directly behind the heart and associated structures allows for better image resolution and avoidance of transthoracic imaging artifacts. Since its initial development, the field of TEE has improved significantly, and the current TEE transducer is flexible, better controlled, and provides up to 28 views, , utilizing four levels of imaging ( Fig. 6.26 ). Standard TEE views are illustrated in Figs. 6.27-6.35 .
The four standard levels of transesophageal probe position
(Adapted from Lang RM. ASE’s Comprehensive Echocardiography. Elsevier- OHCE; 2021.)
Midesophageal four-chamber and two-chamber views. TV-SL , tricuspid valve septal leaflet; TV-AL , tricuspid valve anterior leaflet; RA , right atrium; LA , left atrium; MV-PL , mitral valve posterior leaflet; MV-AL , mitral valve anterior leaflet; CS , coronary sinus.
Midesophageal mitral commissural and long-axis views. MV-PL , mitral valve posterior leaflet; LA , left atrium; CX , circumflex coronary artery; ALPm , anterolateral papillary muscle; PMPm , posteromedial papillary muscle.
Midesophageal aortic valve short axis-view. IA , interatrial septum; RA , right atrium; LA , left atrium; NCC , noncoronary cusp; LCC , left coronary cusp; RCC , right coronary cusp.
Midesophageal aortic valve long-axis view and midesophageal bicaval view. MV-AL , mitral valve anterior leaflet; MV-PL , mitral valve posterior leaflet; LVOT , left ventricular outflow tract; AA , ascending aorta; AV , aortic valve; IA , interatrial septum; LA , left atrium; SVC , superior vena cava; IVC , inferior vena cava; EV , eustachian valve; CT , crista terminalis; RAA , right atrial appendage.
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