Assessing and Managing Cardiac Risk in Noncardiac Surgical Procedures



Assessing and Managing Cardiac Risk in Noncardiac Surgical Procedures


Chetan Vagesh Hampole



I. Introduction

A. Background. Patients undergoing noncardiac surgeries can be at risk for major perioperative cardiac complications, particularly if they are elderly. Worldwide, it is estimated that approximately 500,000 to 900,000 patients per year undergoing noncardiac surgery suffer a perioperative cardiac death, nonfatal myocardial infarction (MI), or nonfatal cardiac arrest. Given the increasingly advanced age of patients undergoing surgeries, this risk is expected to remain substantial. The risk of death from a perioperative MI may be as high as 50%. The elevated risk of perioperative MI is multifactorial and may be primarily due to increased sympathetic tone, a proinflammatory state,
hypercoagulability, and occasional hypoxia during the first few days after surgery. In 1977, Goldman et al. (1) developed a multifactorial index of risk for cardiac morbidity and mortality. Extensive work has subsequently been done on various aspects of perioperative cardiac evaluation, including clinical factors and noninvasive testing. The variety of strategies and practices used has led to high costs associated with preoperative risk assessment. Many studies have recently challenged common practices in the area of perioperative care that were found to have no clear benefit. The American College of Cardiology/American Heart Association (ACC/AHA) Task Force Committee developed practice guidelines aimed at providing a more efficient approach to preoperative evaluation. These guidelines were most recently updated in 2007.

B. Objective. The purpose of preoperative evaluation is not to “clear” patients for an operation. The purpose is to assess current medical status and cardiac risks posed by the planned operation and recommend strategies that may influence shortand long-term outcomes.

1. Although the preoperative assessment is a complex process, a few basic questions and observations by a physician with regard to the patient’s general health, functional capacity, cardiac risk factors, comorbid medical illnesses, and type of anticipated operation can assist in evaluating cardiac risk.

2. It is not prudent to order noninvasive tests for every patient. The physician tries to obtain as much information as possible by means of history and physical examination. Noninvasive tests are requested only if the results are likely to influence treatment and outcome.

3. As a general rule, preoperative intervention is rarely needed unless it is indicated irrespective of the preoperative context. Patients with clinically stable heart disease may not need extensive preoperative testing.

4. Communication is vital among primary physicians, consulting physicians, anesthesiologists, and surgeons for short- and long-term care of patients.


II. CLINICAL PRESENTATION

A. History

1. The clinician needs to identify cardiac conditions that place a patient at increased risk, such as recent MI, decompensated congestive heart failure (CHF), unstable angina, significant arrhythmias, and valvular heart disease.

2. Attention is directed at serious comorbid conditions such as diabetes mellitus, peripheral vascular disease, history of stroke, renal disease, and pulmonary disease.

3. Functional capacity is determined on the basis of the patient’s ability to perform certain daily tasks (Table 34.1).

B. Physical findings. A thorough examination is crucial, and specific findings are addressed.

1. The physical examination includes checking blood pressure in both arms (supine and standing) and evaluation of carotid arterial pulse (character, volume, and upstroke), jugular venous pulsation, cardiac rhythm, heart sounds (murmurs, gallops, or rubs), and extremity pulses.

2. Lung fields are auscultated, and the abdomen is palpated for a possible aneurysm.

3. High-risk findings include severe aortic stenosis murmur, elevated jugular venous pressure, pulmonary edema, or S3 gallop.

C. Indices to predict cardiac risk. Cardiac risk is a function of patient characteristics and the proposed operation.

1. The Goldman index was developed in 1977. The index is a score derived from nine independent variables that predict perioperative cardiac events, and each is assigned a point value (Table 34.2).

2. Detsky et al. (2) developed a modified multifactorial index to address the severity of coronary artery disease (CAD) and heart failure (Table 34.3).









TABLE 34.1 Estimated Energy Requirements for Various Activities































1 to 4 METs


Eat, dress, or use the toilet


Walk indoors around the house


Walk on level ground at 2 mph (3.2 km/h)


Do light housework such as washing dishes


4 to 10 METs


Climb a flight of stairs


Walk on level ground at 4 mph (6.4 km/h)


Run a short distance


Heavy work such as vacuuming or lifting heavy furniture


Play games such as golf or doubles tennis


More than 10 METs


Participate in strenuous activities such as swimming, singles tennis, basketball, or skiing


MET, metabolic equivalent.









TABLE 34.2 Original Goldman Multifactorial Cardiac Risk Index






































































Criteria


Points


History


Age older than 70 y


5


MI in previous 6 mo


10


Physical examination


S3 gallop or JVD


11


Significant AS


3


Electrocardiogram


Rhythm other than sinus or PACs on last preoperative ECG


7


Greater than 5 PVCs/min documented at any time preoperatively


7


General status (one or more of the following)


Po2 < 60 or Pco2 > 50 mm Hg, K < 3.0 or HCO3 < 20 mEq/L, BUN >50 or Cr > 3.0 mg/dL; abnormal AST, signs of chronic liver disease, or patient bedridden from noncardiac causes


3


Operation



Intraperitoneal, intrathoracic, or aortic operation


3



Emergency operation


4


Total


53


Class


Points


Cardiac deaths (%)


I


0-5


0.2


II


6-12


2.0


III


13-25


2.0


IV


≥ 26


56.0


AS, aortic stenosis; AST, aspartate aminotransferase; BUN, blood urea nitrogen; Cr, creatinine; ECG, electrocardiogram; JVD, jugular venous distention; MI, myocardial infarction; PAC, premature atrial contraction; PVC, premature ventricular contraction.


Adapted from Goldman L, Caldera DL, Nussbaum SR, et al. Multifactorial index of cardiac risk in noncardiac surgical procedures. N Engl J Med. 1977;297:845-850.










TABLE 34.3 Detsky’s Modified Cardiac Risk Index






























































Variable


Points


Coronary artery disease


MI within 6 mo earlier


10


MI more than 6 mo earlier


5


Canadian class of angina


Class III


10


Class IV


20


Unstable angina within 3 mo


10


Alveolar pulmonary edema


Within 1 wk


10


Ever


5


Valvular disease


Suspected critical aortic stenosis


20


Arrhythmias


Sinus plus atrial premature beats or rhythm other than sinus on last preoperative electrocardiogram


5


Greater than five ventricular premature beats at any time before operation


5


Poor general medical statusaa


5


Age older than 70 y


5


Emergency operation


10


Total


120


a Defined as any of the following: Po2 < 60 mm Hg, Pco2 > 50 mm Hg, K+ < 3.0, HCO3 < 20 mEq/L, BUN = 18 mmol/L (> 50 mg/dL), serum Cr >260 mmol/L (> 2.9 mg/dL), abnormal AST, signs of chronic liver disease, or patient bedridden because of noncardiac causes. AST, aspartate aminotransferase; BUN, blood urea nitrogen; Cr, creatinine; MI, myocardial infarction.


Adapted from Detsky AS, Abrams HB, McLaughlin JR, et al. Predicting cardiac complications in patients undergoing non-cardiac surgery. J Gen Intern Med. 1986;1:211-219.










TABLE 34.4 Revised Cardiac Risk Index





































Six independent predictors of major cardiac complications


High-risk surgery (intrathoracic, intraperitoneal, or suprainguinal vascular procedures)


History of ischemic heart disease (history of MI or a positive exercise stress test, current complaint of chest pain thought to be due to MI, use of nitrate therapy, or ECG with pathological Q waves; do not count prior coronary revascularization procedure unless one of the other criteria for ischemic heart disease is present)


History of heart failure


History of cerebrovascular disease


Diabetes mellitus requiring insulin therapy


Serum creatinine > 2.0 mg/dL (177 µmol/L)


Rate of cardiac death, nonfatal MI, and nonfatal cardiac arrest according to the number of predictors


No risk factors: 0.4% (95% CI, 0.1-0.8%)


One risk factor: 1.0% (95% CI, 0.5-1.4%)


Two risk factors: 2.4% (95% CI, 1.3-3.5%)


Three or more risk factors: 5.4% (95% CI, 2.8-7.9%)


Rate of cardiac death and nonfatal MI, cardiac arrest or ventricular fibrillation, pulmonary edema, and complete heart block according to the number of predictors and the nonuse or use of β-blockers


No risk factors: 0.4-1.0% versus < 1% with β-blockers


One to two risk factors: 2.2-6.6% versus 0.8-1.6% with β-blockers


Three or more risk factors: > 9% versus > 3% with β-blockers


Adapted from Lee TH, Marcantonio ER, Mangione CM et al. Derivation and prospective validation of a simple index for prediction of cardiac risk of major noncardiac surgery. Circulation. 1999;100:1043-1049.


3. In 1999, Lee et al. (3) developed the Revised Cardiac Risk Index to simplify the process using only six risk factors (Table 34.4). This is now the most widely used risk index and is the one incorporated in the ACC/AHA guidelines.

D. Clinical assessment of risk factors. Instead of dividing risk factors into major, intermediate, and minor groups, the new 2007 ACC/AHA guidelines adopted a more practical approach by recognizing the following conditions:

1. Active cardiac conditions. The presence of one or more of these conditions warrants intensive evaluation and management before proceeding with noncardiac surgery and may result in delay or cancellation of the scheduled surgery (Table 34.5).

2. Clinical risk factors. With the exception of the type of surgery, these factors are the same risk factors identified by the Revised Cardiac Risk Index (Table 34.4), and they include the following:

(a) History of ischemic heart disease

(b) History of compensated or prior heart failure

(c) History of cerebrovascular disease

(d) Diabetes mellitus

(e) Renal insufficiency

3. The original guidelines recognized a group of minor predictors that included advanced age, abnormal electrocardiogram (ECG), rhythm other than sinus, and
uncontrolled hypertension. Although the presence of many of these factors might lead to a higher suspicion of CAD, they have not been shown to increase perioperative risk independently, and therefore, they are no longer incorporated into the recommendations for treatment.








TABLE 34.5 Active Cardiac Conditions That Warrant Evaluation and Treatment before Noncardiac Surgery


































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Jun 7, 2016 | Posted by in CARDIOLOGY | Comments Off on Assessing and Managing Cardiac Risk in Noncardiac Surgical Procedures

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Unstable coronary syndromes


Acute or recent myocardial infarctionaa


Unstable or severebb angina (Canadian class III or IV)cc


Decompensated heart failure


Significant arrhythmias


High-grade atrioventricular block


Mobitz type II atrioventricular block


Third-degree atrioventricular block


Symptomatic ventricular arrhythmias


Supraventricular arrhythmias (including atrial fibrillation) with uncontrolled ventricular rate


Symptomatic bradycardia


Newly recognized ventricular tachycardia


Severe valvular disease


Severe aortic stenosis (mean pressure gradient ≥ 40 mm Hg, aortic valve area ≤1.0 cm2, or symptomatic)


Symptomatic mitral stenosis


a a The American College of Cardiology National Database Library defines acute MI as within 7 d and recent MI as > 7 d and ≤ 1 mo.

b b May include stable angina among patients who are unusually sedentary.

c c Data from Campeau L. Grading of angina pectoris. Circulation. 1976;54:522-523.