Anatomy and Physiology of the Cardiovascular System

At a heart rate of 70 beats per minute, a human heart will contract approximately 100800 times a day, more than 36 million times a year and nearly 3 billion times during an 80-year lifespan.


Fig01-01.jpg


Figure 1.1 – The anatomy of the heart.


1.2 Chambers of the heart



Cardiac chambers In A Heartbeat

















Right atrium



  • Receives venous blood from SVC, IVC, coronary sinus, anterior cardiac veins
  • Separation of smooth and rough areas by crista terminalis
  • Fossa ovalis on interatrial septum

Right ventricle



  • Tricuspid valve: anterior, posterior and septal cusps
  • Pulmonary valve: three semilunar cusps
  • Lined by trabeculae carneae
  • Moderator band conveying right bundle branch to ventricular muscle

Left atrium



  • Receives oxygenated blood from four pulmonary veins
  • Smaller but thicker wall than right atrium

Left ventricle



  • 3× thicker wall than right ventricle (normal thickness 6–10 mm)
  • Lined by trabeculae carneae
  • Mitral valve: anterior and posterior cusps
  • Aortic valve: anterior, right and left posterior cusps

The heart has four chambers: two atria and two ventricles that function to return deoxygenated blood to the lungs and oxygenated blood to the rest of the circulation.


Fig01-02.jpg


Figure 1.2 – The internal anatomy of the heart.


1.2.1 Right atrium



  • Forms the entire right border
  • Receives venous blood from the:

    • superior vena cava superiorly, draining the azygos, subclavian and jugular veins
    • inferior vena cava inferiorly, draining the lower body
    • coronary sinus inferiorly, draining the heart
    • anterior cardiac veins anteriorly, draining the anterior heart

  • Anterior part of wall is smooth
  • Posterior part of wall is rough with trabeculations known as musculi pectinati (pectinate muscles) derived from the true fetal atrium
  • Crista terminalis is a muscular ridge that runs vertically downwards, separating the smooth and rough parts
  • Right auricle/atrial appendage is a cone-shaped muscular pouch-like extension of the right atrium
  • Fossa ovalis is a shallow oval depression in the interatrial septum

    • an embryonic remnant of the fetal foramen ovale.

1.2.2 Right ventricle



  • Forms most of the inferior border and anterior surface of the heart
  • Connected to the right atrium by the tricuspid valve which has three cusps: anterior, posterior and septal
  • Connected to the pulmonary trunk by the pulmonary valve comprising three semilunar cusps
  • Each cusp is connected to its corresponding papillary muscle by chordae tendinae (heart strings)
  • Trabeculae carneae are irregular ridges lining the wall
  • Moderator band is a muscular bundle connecting the interventricular septum to the anterior wall

    • conveys the right bundle branch to the ventricular muscle

  • Infundibulum is the smooth-walled outflow tract directed upwards and right towards the pulmonary trunk.

Fig01-03.jpg


Figure 1.3 – Superior view of heart valves.


1.2.3 Left atrium



  • Forms most of the base of the heart
  • Smaller, but thicker walled than right atrium
  • Receives oxygenated blood from the four pulmonary veins which open into the cavity on its posterior wall (two from each lung: superior and inferior)
  • Left auricle/atrial appendage is an ear-shaped muscular pouch extending forwards and to the right

    • this is a common site for thrombus formation

  • Mainly smooth-walled except for ridges in the auricle due to underlying pectinate muscles.

1.2.4 Left ventricle



  • Forms most of the left border and the apex of the heart
  • Longer, more conical and thicker walled than the right atrium (three times thicker, between 6 and 10 mm in a normal heart)
  • Wall is lined by thick trabeculae carneae
  • Joined to left atrium by mitral valve
  • Mitral valve has two cusps: anterior and posterior
  • Chordae tendinae connects each cusp to its corresponding papillary muscle
  • Communicates with aorta via the aortic valve:

    • 3 semilunar cusps: anterior, right and left posterior
    • anterior and left posterior aortic sinuses above the valve give rise to the right and left coronary arteries respectively.


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  • ‘Pectinate’ means ‘like a comb’ in Latin
  • The mitral valve gains its name from its resemblance to a bishop’s mitre
  • A patent foramen ovale is found in 20% of adults and is usually asymptomatic
  • Rupture of any papillary muscle, such as following a myocardial infarction, will cause the valve cusp to prolapse, resulting in severe regurgitation.

1.3 Coronary circulation



Coronary circulation In A Heartbeat














Right coronary artery



  • Originates from anterior aortic sinus, runs along atrioventricular (AV) groove
  • Major branches: sinoatrial nodal, posterior descending, AV nodal, marginal

Left coronary artery



  • Originates from left posterior aortic sinus
  • Major branches: left anterior descending, left circumflex

Coronary veins



  • Great, middle, small and oblique cardiac veins drain into the coronary sinus then into the right atrium

1.3.1 Coronary arteries


The heart has a high oxygen demand from continuous pumping of blood. This demand is met by the left and right coronary arteries.


Fig01-04.jpg


Figure 1.4 – The coronary vessels.


Right coronary artery



  • Originates from the anterior aortic sinus
  • Passes forwards between pulmonary trunk and right auricle
  • Runs along the atrioventricular (AV) groove
  • Continues to the inferior border of heart to anastamose with the circumflex branch of the left coronary artery
  • Major branches:

    • sinoatrial (SA) nodal artery runs posteriorly between the right auricle and aorta, supplying the SA node
    • marginal artery along the inferior border of the heart
    • posterior descending/posterior interventricular artery descends in the posterior interventricular groove to anastamose with the left anterior descending artery at the apex
    • AV nodal artery arises from the characteristic loop where the posterior descending artery originates to supply the AV node.

Left coronary artery



  • Originates from the left posterior aortic sinus
  • Larger than the right coronary artery
  • Left main stem varies in length (4–20 mm)

    • known as the ‘widowmaker’ as occlusion leads to rapid death

  • Initially passes behind then to the left of the pulmonary trunk
  • Reaches the left part of the AV groove
  • Runs laterally around the left border as the left circumflex artery to reach the posterior interventricular groove
  • Major branches:

    • left anterior descending (LAD)/anterior interventricular:

      – descends in the anterior interventricular groove to anastamose with the posterior descending artery at the apex


    • left circumflex (LCX):

      – continues round the left side of the heart in the atrioventricular groove, giving off various ventricular and atrial branches


      – anastamoses with the terminal branches of the right coronary artery.



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Knowledge of the major and minor branches of the coronary arteries is essential for coronary angiogram interpretation. Figure 1.5 is a schematic of the arteries as visualised in a typical coronary angiogram.




















RCA = right coronary


LAD = left anterior descending


RDP = posterior descending


D1 = first diagonal branch of LAD


RPL = right posterolateral branch


M1 = first marginal branch of LCX


LCX = left circumflex


MO1 = first marginal obtuse branch of LCX


Fig01-05.jpg


Figure 1.5 – Schematic of coronary arteries as visualised in a typical angiogram.


Anatomical variations



  • 90% of the population are ‘right dominant’ – where the posterior descending/posterior interventricular artery branches from the right coronary artery. In the ‘left dominant’ 10%, the left coronary and circumflex arteries may be larger and branch off the posterior descending artery before anastomosing with an unusually smaller right coronary artery.
  • The SA node is supplied by the right coronary in 60% and the left circumflex artery in nearly 40% of the population. Dual supply is present in 3%.
  • The AV node is supplied by the right coronary artery in 90% of the population, with the remaining 10% by the left circumflex.


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  • The coronary arteries originate from the aortic sinuses – small openings superior to the cusps of the aortic valve. This makes coronary arteries the first branches of the aorta
  • Coronary blood flow is about 250 ml/min at rest (5% of cardiac output) and rises to 1 L/min during exercise
  • During systole (contraction), the aortic valves open and blood is ejected into the aorta. When the aortic valves close during diastole (when the heart is at rest), blood in the aorta flows into the aortic sinuses then into the coronary arteries to supply the heart
  • Coronary flow takes place mainly during diastole. It is reduced during systole when the intramyocardial arteries are compressed by the contracting muscle
  • Therefore, diastolic perfusion time is important for the coronary circulation. This is shortened by a rapid heart rate which may result in inadequate perfusion.

1.3.2 Coronary veins


Most of the heart’s venous drainage is fulfilled by the tributaries of the coronary sinus.


The coronary sinus runs in the posterior atrioventricular groove. It opens into the right atrium just to the left of the opening of the inferior vena cava. Its orifice is guarded by the Thebesian valve. Its tributaries are:



  • the great cardiac vein in the anterior interventricular groove
  • the middle cardiac vein in the inferior interventricular groove
  • the small cardiac vein that accompanies the marginal artery along the inferior border of the heart
  • the oblique vein which descends obliquely on the posterior side of the left atrium.

The remaining venous drainage is fulfilled by:



  • the anterior cardiac veins (3 or 4 of them) draining a large proportion of the anterior surface of the heart directly into the right atrium
  • small veins (venae cordis minimae) within each chamber wall draining directly into their respective chambers.

1.4 Conducting system of the heart



Conducting system In A Heartbeat

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Apr 3, 2017 | Posted by in CARDIOLOGY | Comments Off on Anatomy and Physiology of the Cardiovascular System

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