Before Mec/Sal
After Mec/Sal 30 min
30
1 h
2 h
3 h
4 h
5 h
Mean airway pressure (MAP, kPa)
Sal
0.26 ± 0.02
0.59 ± 0.05
0.55 ± 0.03
0.58 ± 0.03
0.55 ± 0.01
0.51 ± 0.03
0.54 ± 0.04
0.57 ± 0.03
Mec
0.30 ± 0.01
0.91 ± 0.03c
0.97 ± 0.04c
1.00 ± 0.03c
1.03 ± 0.03c
1.02 ± 0.04c
1.04 ± 0.02c
1.09 ± 0.02c
Mec + NAC
0.28 ± 0.01
0.86 ± 0.01
0.90 ± 0.04
0.92 ± 0.04
0.92 ± 0.04d
0.89 ± 0.04d
0.93 ± 0.03
0.92 ± 0.03f
Oxygenation index (OI)
Sal
0.6 ± 0.1
3.0 ± 0.6
3.3 ± 0.7
2.1 ± 0.4
1.8 ± 0.3
1.7 ± 0.2
2.2 ± 0.4
1.4 ± 0.1
Mec
0.8 ± 0.1
12.5 ± 1.4c
14.2 ± 0.9c
14.7 ± 0.9c
16.6 ± 1.1c
17.1 ± 1.6c
16.5 ± 1.3c
18.1 ± 1.3c
Mec + NAC
0.7 ± 0.1
11.1 ± 1.0
9.7 ± 1.5e
8.2 ± 1.3f
8.2 ± 1.1f
7.8 ± 1.1f
8.8 ± 1.2f
9.1 ± 1.3f
PaO 2 /FiO 2
Sal
9.4 ± 0.9
24.7 ± 4.7
23.1 ± 5.5
37.4 ± 7.1
34.8 ± 4.9
34.0 ± 3.7
29.2 ± 3.6
42.0 ± 3.2
Mec
8.3 ± 0.5
7.3 ± 0.6c
6.9 ± 0.4b
6.9 ± 0.4c
6.3 ± 0.3c
6.2 ± 0.4c
6.4 ± 0.4c
6.1 ± 0.4c
Mec + NAC
8.0 ± 0.5
8.0 ± 0.7
10.0 ± 1.1
12.4 ± 1.7
12.2 ± 1.3
12.4 ± 1.5
11.5 ± 1.4
11.0 ± 1.2
Right-to-left pulmonary shunts (RLS, %)
Sal
17.6 ± 5.0
38.2 ± 1.7
36.8 ± 3.5
31.2 ± 3.6
30.1 ± 3.2
27.0 ± 2.8
28.3 ± 2.0
23.2 ± 2.7
Mec
16.9 ± 3.1
54.8 ± 6.0
58.5 ± 6.8b
57.7 ± 4.3c
60.6 ± 2.4c
60.0 ± 1.9c
61.5 ± 1.7c
63.1 ± 3.4c
Mec + NAC
18.5 ± 3.4
48.3 ± 4.2
44.7 ± 3.0d
39.2 ± 4.1e
34.6 ± 4.2f
35.0 ± 3.9f
35.3 ± 4.1f
33.3 ± 3.2f
3.2 Cells in BAL Fluid and in Arterial Blood
After meconium instillation, the total count of leukocytes decreased in arterial blood (Fig. 1) and increased in BAL fluid (Fig. 2) in the Mec group compared with the control level in the Sal group (both p < 0.001); NAC reversed these effects to a major extent. The percentage changes in neutrophils closely followed changes in the absolute counts of leukocytes in both compartments.
Fig. 1
Total count of leukocytes in arterial blood at the end of experiment. Between-group differences: Mec vs. Sal: *p < 0.001; Mec + NAC vs. Mec: #p < 0.05
Fig. 2
Total count o f cells in BAL fluid at the end of experiment. Between-group differences: Mec vs. Sal: *p < 0.001; Mec + NAC vs. Mec: #p < 0.05
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