Adverse outcomes in patients prescribed a proton pump inhibitor following percutaneous coronary intervention with drug-eluting stents




Background


Recent evidence shows that clopidogrel and proton pump inhibitors (PPI) are metabolized by the same pathway, and patients taking both drugs have higher levels of platelet reactivity and more adverse outcomes than patients taking only clopidogrel.




Methods


Following percutaneous coronary intervention (PCI) with drug-eluting stents (DES), we compared 502 patients not prescribed a PPI at discharge to 318 patients prescribed a PPI; all patients were on clopidogrel. Patients were followed for 1 year for major adverse cardiac events (MACE), including death, Q-wave myocardial infarction, stent thrombosis, and target vessel revascularization. We performed multivariable Cox regression to adjust for confounders, including compliance with clopidogrel, to assess the effect of a PPI at discharge upon 1-year outcomes.




Methods


Following percutaneous coronary intervention (PCI) with drug-eluting stents (DES), we compared 502 patients not prescribed a PPI at discharge to 318 patients prescribed a PPI; all patients were on clopidogrel. Patients were followed for 1 year for major adverse cardiac events (MACE), including death, Q-wave myocardial infarction, stent thrombosis, and target vessel revascularization. We performed multivariable Cox regression to adjust for confounders, including compliance with clopidogrel, to assess the effect of a PPI at discharge upon 1-year outcomes.

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Nov 16, 2017 | Posted by in CARDIOLOGY | Comments Off on Adverse outcomes in patients prescribed a proton pump inhibitor following percutaneous coronary intervention with drug-eluting stents

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